Journal article
CD40-Mediated Activation of the NF-κB2 Pathway
Frontiers in immunology, Vol.4, pp.376-376
2013
DOI: 10.3389/fimmu.2013.00376
PMID: 24298274
Abstract
CD40 is a critical stimulatory receptor on antigen-presenting cells of the immune system. CD40-mediated activation of B cells is particularly important for normal humoral immune function. Engagement of CD40 by its ligand, CD154, on the surface of activated T cells initiates a variety of signals in B cells including the activation of MAP kinases and NF-κB. The transcriptional regulator NF-κB is in reality a family of factors that can promote B cell activation, differentiation, and proliferation. Complex – and only partially understood – biochemical mechanisms allow CD40 to trigger two distinct NF-κB activation pathways resulting in the activation of canonical (NF-κB1) and non-canonical (NF-κB2) NF-κB. This brief review provides a summary of mechanisms responsible for activation of the latter, which appears to be particularly important for enhancing the viability of B cells at various stages in their life cycle and may also contribute to the development of B cell malignancies. CD40 is also expressed by various cell types in addition to B cells, including T cells, macrophages, dendritic cells, as well as certain non-hematopoietic cells. Here too, while perhaps less extensively studied than in B cells, the CD40-mediated activation of NF-κB2 also appears to have important roles in cellular physiology.
Details
- Title: Subtitle
- CD40-Mediated Activation of the NF-κB2 Pathway
- Creators
- Bruce S Hostager - ,Gail A Bishop - ,
- Resource Type
- Journal article
- Publication Details
- Frontiers in immunology, Vol.4, pp.376-376
- DOI
- 10.3389/fimmu.2013.00376
- PMID
- 24298274
- NLM abbreviation
- Front Immunol
- ISSN
- 1664-3224
- eISSN
- 1664-3224
- Publisher
- Frontiers Media S.A
- Language
- English
- Date published
- 2013
- Academic Unit
- Microbiology and Immunology; President
- Record Identifier
- 9984001215302771
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