Journal article
CD40 and autoimmunity: The dark side of a great activator
Seminars in immunology, Vol.21(5), pp.293-300
2009
DOI: 10.1016/j.smim.2009.05.012
PMCID: PMC2753170
PMID: 19595612
Abstract
CD40 is a tumor necrosis factor receptor superfamily member expressed by immune and non-immune cells. CD40:CD154 interactions mediate T-dependent B cell responses and efficient T cell priming. Thus, CD40 is a likely candidate to play roles in autoimmune diseases in which activated T and B cells cause pathology. Diseases in which CD40 plays a pathogenic role include autoimmune thyroiditis, type 1 diabetes, inflammatory bowel disease, psoriasis, multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematosus. This review discusses the role of CD40:CD154 interaction in human and mouse autoimmunity, human polymorphisms associated with disease incidence, and disrupting CD40:CD154 interactions as an autoimmune therapy.
Details
- Title: Subtitle
- CD40 and autoimmunity: The dark side of a great activator
- Creators
- Anna L Peters - Immunology Graduate Program and Medical Scientist Training Program, University of Iowa, Iowa City, IA 52242, United StatesLaura L Stunz - Dept. of Microbiology, University of Iowa, Iowa City, United StatesGail A Bishop - Immunology Graduate Program and Medical Scientist Training Program, University of Iowa, Iowa City, IA 52242, United States
- Resource Type
- Journal article
- Publication Details
- Seminars in immunology, Vol.21(5), pp.293-300
- DOI
- 10.1016/j.smim.2009.05.012
- PMID
- 19595612
- PMCID
- PMC2753170
- NLM abbreviation
- Semin Immunol
- ISSN
- 1044-5323
- eISSN
- 1096-3618
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 2009
- Academic Unit
- Microbiology and Immunology; President
- Record Identifier
- 9984001212102771
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