Journal article
CD4+CD25+ immunoregulatory T cells may not be involved in controlling autoimmune arthritis
Arthritis research & therapy, Vol.5(2), pp.R106-R113
2003
DOI: 10.1186/ar624
PMCID: PMC165034
PMID: 12718754
Abstract
Accumulating evidence suggests that regulatory T cells play a crucial role in preventing autoimmunity. Recently, a naturally occurring CD4
+
CD25
+
T-cell subset that is anergic and also suppressive has been shown to suppress autoimmunity in several animal models. We used proteoglycan-induced arthritis (PGIA) as a study model to investigate the role of the CD4
+
CD25
+
regulatory T cells in autoimmune arthritis. There was no significant change in the percentage of CD4
+
CD25
+
T cells during the immunization period when proteoglycan- or ovalbumin-immunized BALB/c and C57BL/6 mice were compared. An adoptive transfer study showed that the CD4
+
CD25
+
T cells did not protect severe combined immunodeficient mice from arthritis when they were cotransferred with splenocytes from arthritic animals. Similarly, depletion of the CD4
+
CD25
+
T cells did not enhance the onset of the disease or disease severity in severe combined immunodeficient mice. Moreover, CD28-deficient mice, which have very few CD4
+
CD25
+
T cells, were highly resistant to PGIA. These findings indicate that the CD4
+
CD25
+
regulatory T cells may not play a critical role in controlling PGIA.
Details
- Title: Subtitle
- CD4+CD25+ immunoregulatory T cells may not be involved in controlling autoimmune arthritis
- Creators
- Tamas Bardos - Section of Biochemistry and Molecular Biology, Department of Orthopedic Surgery, Rush University at Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois, USAMatyas Czipri - Section of Biochemistry and Molecular Biology, Department of Orthopedic Surgery, Rush University at Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois, USACsaba Vermes - Section of Biochemistry and Molecular Biology, Department of Orthopedic Surgery, Rush University at Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois, USAAlison Finnegan - Department Internal Medicine, Rush University at Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois, USAKatalin Mikecz - Section of Biochemistry and Molecular Biology, Department of Orthopedic Surgery, Rush University at Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois, USAJian Zhang - Section of Biochemistry and Molecular Biology, Department of Orthopedic Surgery, Rush University at Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois, USA
- Resource Type
- Journal article
- Publication Details
- Arthritis research & therapy, Vol.5(2), pp.R106-R113
- Publisher
- BioMed Central; London
- DOI
- 10.1186/ar624
- PMID
- 12718754
- PMCID
- PMC165034
- ISSN
- 1478-6354
- eISSN
- 1478-6362
- Language
- English
- Date published
- 2003
- Academic Unit
- Pathology
- Record Identifier
- 9984047663402771
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