Journal article
CD8 + T cell contraction is controlled by early inflammation
Nature immunology, Vol.5(8), pp.809-817
08/2004
DOI: 10.1038/ni1098
PMID: 15247915
Abstract
Pathogen-specific CD8(+) T cells expand in number after infection and then their numbers invariably contract by 90-95%, leaving a stable memory cell pool. The chief features of this response are programmed early after infection; however, the factors regulating contraction are mostly undefined. Here we show that antibiotic treatment before Listeria monocytogenes infection induced numbers of protective memory CD8(+) T cells similar to those in control infected mice, by a pathway without contraction. The absence of contraction correlated with decreased early inflammation and interferon-gamma production and an increased fraction of CD8(+) T cells expressing the interleukin 7 receptor at the peak of the response. Thus, contraction is controlled by early inflammation but is not essential for the generation of protective memory CD8(+) T cells after infection.
Details
- Title: Subtitle
- CD8 + T cell contraction is controlled by early inflammation
- Creators
- Brandon B Porter - Interdisciplinary Graduate Program in Immunology, University of IowaJohn T Harty - Department of Microbiology, University of Iowa Interdisciplinary Graduate Program in Immunology, University of IowaVladimir P Badovinac - Department of Microbiology, University of Iowa
- Resource Type
- Journal article
- Publication Details
- Nature immunology, Vol.5(8), pp.809-817
- DOI
- 10.1038/ni1098
- PMID
- 15247915
- ISSN
- 1529-2908
- eISSN
- 1529-2916
- Language
- English
- Date published
- 08/2004
- Academic Unit
- Microbiology and Immunology; Pathology
- Record Identifier
- 9984047778902771
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