Journal article
CD8 + T-cell homeostasis after infection: setting the ‘curve’
Microbes and Infection, Vol.4(4), pp.441-447
2002
DOI: 10.1016/S1286-4579(02)01558-7
PMID: 11932195
Abstract
Antigen (Ag)-specific CD8
+ T-cell responses exhibit remarkably similar kinetics after different types of infection. Starting from levels that are virtually undetectable in vivo, pathogen-specific naïve CD8
+ T cells are precisely regulated to go through rapid expansion and contraction (death) phases, achieving memory levels of Ag-specific CD8
+ T cells that are maintained for the life of the host. However, the exact mechanisms used to achieve appropriate and reproducible CD8
+ T-cell homeostasis in response to diverse pathogens remain to be determined. The possibility that early events after infection regulate major features of Ag-specific CD8
+ T-cell homeostasis will be discussed here.
Details
- Title: Subtitle
- CD8 + T-cell homeostasis after infection: setting the ‘curve’
- Creators
- Vladimir P Badovinac - Department of Microbiology, University of Iowa, 3-512 Bowen Science Building, 51 Newton Road, Iowa City, IA 52242, USAJohn T Harty - Department of Microbiology, University of Iowa, 3-512 Bowen Science Building, 51 Newton Road, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Microbes and Infection, Vol.4(4), pp.441-447
- Publisher
- Elsevier SAS
- DOI
- 10.1016/S1286-4579(02)01558-7
- PMID
- 11932195
- ISSN
- 1286-4579
- eISSN
- 1769-714X
- Language
- English
- Date published
- 2002
- Academic Unit
- Microbiology and Immunology; Pathology
- Record Identifier
- 9984047769702771
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