CD8 T cell memory development: CD4 T cell help is appreciated

Aaruni Khanolkar; Vladimir Badovinac; John Harty

doi:10.1007/s12026-007-0081-4

Back

CD8 T cell memory development: CD4 T cell help is appreciated

Journal article

Peer reviewed

CD8 T cell memory development: CD4 T cell help is appreciated

Aaruni Khanolkar, Vladimir Badovinac and John Harty

Immunologic research, Vol.39(1), pp.94-104

11/2007

DOI: 10.1007/s12026-007-0081-4

PMID: 17917058

View Online

Abstract

An important goal of vaccination strategies is to elicit long term, effective immunity. Therefore it is imperative to define the parameters that regulate the development and preservation of the numbers and functional quality of cells that confer this property to the host. CD8 T cells are a key component of the host adaptive immune response that helps eradicate invading viruses and other cell-associated pathogens. Once the primary infection is controlled, the CD8 T cells transition from being effector cells into memory cells that act as sentinels of the immune system capable of rapidly purging the host of recurrent infections by the same pathogen. The factors that regulate and orchestrate this transition from effector CD8 T cells into functionally robust memory CD8 T cells are poorly understood. In recent years it has been determined that CD4 T cells play a vital role in the survival and functional responsiveness of memory CD8 T cells. However, the mechanism(s) of this interaction are still unclear.

Immunization

Cytokines

Rechallenge

Memory

Internal Medicine

Proliferation

Medicine/Public Health, general

Adoptive transfer

Allergology

Unhelped

Immunology

Medicine & Public Health

Helped

Details

Title: Subtitle: CD8 T cell memory development: CD4 T cell help is appreciated
Creators: Aaruni Khanolkar - Department of Microbiology University of Iowa 3-512 Bowen Science Building Iowa City IA 52242 USA
Vladimir Badovinac - Department of Microbiology University of Iowa 3-512 Bowen Science Building Iowa City IA 52242 USA
John Harty - Interdisciplinary Graduate Program in Immunology University of Iowa Iowa City IA USA
Resource Type: Journal article
Publication Details: Immunologic research, Vol.39(1), pp.94-104
DOI: 10.1007/s12026-007-0081-4
PMID: 17917058
NLM abbreviation: Immunol Res
ISSN: 0257-277X
eISSN: 1559-0755
Publisher: Humana Press Inc; New York
Language: English
Date published: 11/2007
Academic Unit: Microbiology and Immunology; Pathology
Record Identifier: 9984047859202771

Metrics

35 Record Views

55 Times Cited - Web of Science