Journal article
CD8 T cells can protect against an intracellular bacterium in an interferon gamma-independent fashion
Proceedings of the National Academy of Sciences - PNAS, Vol.89(23), pp.11612-11616
12/01/1992
DOI: 10.1073/pnas.89.23.11612
PMCID: PMC50603
PMID: 1360672
Abstract
Specific T-cell immunity to Listeria monocytogenes is thought to occur through the action of lymphokines which activate phagocytes to ingest and kill microorganisms. Interferon gamma (IFN-gamma) has been shown to be an effective mediator of this type of macrophage activation in vivo and in vitro. The monoclonal antibody H22.1 efficiently neutralizes endogenous IFN-gamma, exacerbates disease in a mouse model of L. monocytogenes infection, and inhibits the in vivo protective activity of a Listeria antigen-specific CD4 T-cell line. In contrast, in vivo protection by Listeria-immune CD8 T cells is not inhibited by the neutralizing anti-IFN-gamma monoclonal antibody. These results suggest that CD8 T cells can protect against an intracellular pathogen in an IFN-gamma-independent manner.
Details
- Title: Subtitle
- CD8 T cells can protect against an intracellular bacterium in an interferon gamma-independent fashion
- Creators
- John T Harty - Howard Hughes Medical Institute, Seattle, WARobert D Schreiber - Howard Hughes Medical Institute, Seattle, WAMichael J Bevan - Howard Hughes Medical Institute, Seattle, WA
- Resource Type
- Journal article
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, Vol.89(23), pp.11612-11616
- DOI
- 10.1073/pnas.89.23.11612
- PMID
- 1360672
- PMCID
- PMC50603
- NLM abbreviation
- Proc Natl Acad Sci U S A
- ISSN
- 0027-8424
- eISSN
- 1091-6490
- Publisher
- National Academy of Sciences
- Language
- English
- Date published
- 12/01/1992
- Academic Unit
- Pathology
- Record Identifier
- 9984047618302771
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