CD8 T cells inhibit respiratory syncytial virus (RSV) vaccine-enhanced disease

Matthew R Olson; Steven M Varga

doi:10.4049/jimmunol.179.8.5415

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CD8 T cells inhibit respiratory syncytial virus (RSV) vaccine-enhanced disease

Journal article

Peer reviewed

CD8 T cells inhibit respiratory syncytial virus (RSV) vaccine-enhanced disease

Matthew R Olson and Steven M Varga

The Journal of immunology (1950), Vol.179(8), pp.5415-5424

10/15/2007

DOI: 10.4049/jimmunol.179.8.5415

PMID: 17911628

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Abstract

Vaccination of children with a formalin-inactivated (FI) respiratory syncytial virus (RSV) vaccine led to exacerbated disease including pulmonary eosinophilia following a natural RSV infection. Immunization of BALB/c mice with FI-RSV or a recombinant vaccinia virus (vv) expressing the RSV attachment (G) protein (vvG) results in a pulmonary Th2 response and eosinophilia after RSV challenge that closely mimics the RSV vaccine-enhanced disease observed in humans. The underlying causes of RSV vaccine-enhanced disease remain poorly understood. We demonstrate here that RSV M2-specific CD8 T cells reduce the Th2-mediated pathology induced by vvG-immunization and RSV challenge in an IFN-gamma-independent manner. We also demonstrate that FI-RSV immunization does not induce a measurable RSV-specific CD8 T cell response and that priming FI-RSV-immunized mice for a potent memory RSV-specific CD8 T cell response abrogates pulmonary eosinophilia after subsequent RSV challenge. Our results suggest that the failure of the FI-RSV vaccine to induce a CD8 T cell response may have contributed to the development of pulmonary eosinophilia and augmented disease that occurred in vaccinated individuals.

Pulmonary Eosinophilia - prevention & control

Respiratory Syncytial Virus Vaccines - immunology

Pulmonary Eosinophilia - virology

Respiratory Syncytial Viruses - immunology

Th2 Cells - immunology

Lymphocyte Depletion

Respiratory Syncytial Virus Infections - immunology

Immunosuppression

Animals

CD8-Positive T-Lymphocytes - virology

Respiratory Syncytial Virus Infections - prevention & control

Female

Immunologic Memory

Mice

Mice, Inbred BALB C

Epitopes, T-Lymphocyte - immunology

Kinetics

CD8-Positive T-Lymphocytes - immunology

Respiratory Syncytial Virus Infections - virology

Th2 Cells - pathology

Pulmonary Eosinophilia - immunology

Details

Title: Subtitle: CD8 T cells inhibit respiratory syncytial virus (RSV) vaccine-enhanced disease
Creators: Matthew R Olson - Department of Microbiology, University of Iowa, IA 52242, USA
Steven M Varga
Resource Type: Journal article
Publication Details: The Journal of immunology (1950), Vol.179(8), pp.5415-5424
DOI: 10.4049/jimmunol.179.8.5415
PMID: 17911628
NLM abbreviation: J Immunol
ISSN: 0022-1767
eISSN: 1550-6606
Grant note: T32AI007533 / NIAID NIH HHS AI 063520 / NIAID NIH HHS
Language: English
Date published: 10/15/2007
Academic Unit: Graduate College Admin and Gen; Microbiology and Immunology; Pathology
Record Identifier: 9984083868102771

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