Journal article
CF-carrier state associated with more severe cases of bronchiectasis
Open forum infectious diseases, Vol.11(2), ofae024
02/01/2024
DOI: 10.1093/ofid/ofae024
PMCID: PMC10883289
PMID: 38390464
Abstract
Abstract Background People with CF are at increased risk for bronchiectasis and several reports suggest that CF carriers may also be at higher risk for developing bronchiectasis. The purpose of this paper was to determine if CF carriers are at risk for more severe courses or complications of bronchiectasis. Methods Using Marketscan data (2001-2021), we built a cohort consisting of 105 CF carriers with bronchiectasis and 300083 controls with bronchiectasis but without a CF carrier diagnosis. We evaluated if CF carriers were more likely to be hospitalized for bronchiectasis. In addition, we examined if CF carriers were more likely to be infected with Pseudomonas aeruginosa or non-tuberculous mycobacteria (NTM) or to have filled more antibiotic prescriptions. We considered regression models for both incident and rate outcomes that controlled for age, sex, smoking status, and comorbidities. Results The odds of hospitalization were almost 2.4 times higher (95% CI: 1.116, 5.255) for CF carriers with bronchiectasis compared to non-CF carriers with bronchiectasis. The estimated odds of being diagnosed with a Pseudomonas infection for CF carriers compared to non-carriers was about 4.2 times higher (95% CI 2.417, 7.551) and about 5.4 times higher (95% CI: 3.398, 8.804) for being diagnosed with NTM. The rate of distinct antibiotic fill dates was estimated to be about 2 times higher for carriers compared to controls (95% CI: 1.735 to 2.333), and the rate ratio for the total number of days of antibiotics supplied was estimated to be about 2.8 (95% CI 2.290 to 3.442). Conclusion CF carriers withbronchiectasis required more hospitalizations and more frequent administration of antibiotics compared to non-carriers. Given that CF carriers were also more likely to be diagnosed with Pseudomonas and NTM infections, CF carriers with bronchiectasis may have a phenotype more resembling CF-related bronchiectasis than non-CF bronchiectasis.
Details
- Title: Subtitle
- CF-carrier state associated with more severe cases of bronchiectasis
- Creators
- Aaron C Miller - University of IowaLogan M Harris - University of IowaKevin Winthrop - Oregon Health & Science UniversityJoseph E Cavanaugh - University of IowaMahmoud H Abou AlaiwaDouglas B Hornick - University of IowaDavid A Stoltz - University of IowaPhilip M Polgreen - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Open forum infectious diseases, Vol.11(2), ofae024
- DOI
- 10.1093/ofid/ofae024
- PMID
- 38390464
- PMCID
- PMC10883289
- NLM abbreviation
- Open Forum Infect Dis
- ISSN
- 2328-8957
- eISSN
- 2328-8957
- Grant note
- DOI: 10.13039/100000060, name: National Institute of Allergy and Infectious Diseases, award: 5R01HS027375; DOI: 10.13039/100006108, name: National Center for Advancing Translational Sciences, award: UL1TR002537
- Language
- English
- Electronic publication date
- 01/17/2024
- Date published
- 02/01/2024
- Academic Unit
- Statistics and Actuarial Science; Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; Infectious Diseases; Epidemiology; Biostatistics; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984548465802771
Metrics
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