Journal article
CGRP as a neuropeptide in migraine: lessons from mice
British journal of clinical pharmacology, Vol.80(3), pp.403-414
09/2015
DOI: 10.1111/bcp.12686
PMCID: PMC4574826
PMID: 26032833
Abstract
Migraine is a neurological disorder that is far more than just a bad headache. A hallmark of migraine is altered sensory perception. A likely contributor to this altered perception is the neuropeptide calcitonin gene-related peptide (CGRP). Over the past decade, CGRP has become firmly established as a key player in migraine. Although the mechanisms and sites of action by which CGRP might trigger migraine remain speculative, recent advances with mouse models provide some hints. This brief review focuses on how CGRP might act as both a central and peripheral neuromodulator to contribute to the migraine-like symptom of light aversive behaviour in mice.
Details
- Title: Subtitle
- CGRP as a neuropeptide in migraine: lessons from mice
- Creators
- Andrew F Russo - Veterans Affairs Medical Center, Iowa City, IA, 52246, USA
- Resource Type
- Journal article
- Publication Details
- British journal of clinical pharmacology, Vol.80(3), pp.403-414
- DOI
- 10.1111/bcp.12686
- PMID
- 26032833
- PMCID
- PMC4574826
- NLM abbreviation
- Br J Clin Pharmacol
- ISSN
- 0306-5251
- eISSN
- 1365-2125
- Publisher
- England
- Grant note
- R01 NS075599 / NINDS NIH HHS
- Language
- English
- Date published
- 09/2015
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute; Craniofacial Anomalies Research Center
- Record Identifier
- 9984020786002771
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