Journal article
CGRP induces migraine-like symptoms in mice during both the active and inactive phases
Journal of headache and pain, Vol.22(1), pp.62-62
06/30/2021
DOI: 10.1186/s10194-021-01277-9
PMCID: PMC8243868
PMID: 34193048
Abstract
Background: Circadian patterns of migraine attacks have been reported by patients but remain understudied. In animal models, circadian phases are generally not taken into consideration. In particular, rodents are nocturnal animals, yet they are most often tested during their inactive phase during the day. This study aims to test the validity of CGRP-induced behavioral changes in mice by comparing responses during the active and inactive phases. Methods: Male and female mice of the outbred CD1 strain were administered vehicle (PBS) or CGRP (0.1 mg/kg, i.p.) to induce migraine-like symptoms. Animals were tested for activity (homecage movement and voluntary wheel running), light aversive behavior, and spontaneous pain at different times of the day and night. Results: Peripheral administration of CGRP decreased the activity of mice during the first hour after administration, induced light aversive behavior, and spontaneous pain during that same period of time. Both phenotypes were observed no matter what time of the day or night they were assessed. Conclusions: A decrease in wheel activity is an additional clinically relevant phenotype observed in this model, which is reminiscent of the reduction in normal physical activity observed in migraine patients. The ability of peripheral CGRP to induce migraine-like symptoms in mice is independent of the phase of the circadian cycle. Therefore, preclinical assessment of migraine-like phenotypes can likely be done during the more convenient inactive phase of mice.
Details
- Title: Subtitle
- CGRP induces migraine-like symptoms in mice during both the active and inactive phases
- Creators
- Anne-Sophie Wattiez - 51 Newton Rd, Iowa City, IA 52242 USAOlivia J Gaul - 51 Newton Rd, Iowa City, IA 52242 USAAdisa Kuburas - 51 Newton Rd, Iowa City, IA 52242 USAErik Zorilla - Iowa City, IA 52242 USAJayme S Waite - 51 Newton Rd, Iowa City, IA 52242 USABianca N Mason - 51 Newton Rd, Iowa City, IA 52242 USAWilliam C Castonguay - 51 Newton Rd, Iowa City, IA 52242 USAMengya Wang - Iowa City, IA 52242 USABennett R Robertson - 51 Newton Rd, Iowa City, IA 52242 USAAndrew F Russo - 51 Newton Rd, Iowa City, IA 52242 USA
- Resource Type
- Journal article
- Publication Details
- Journal of headache and pain, Vol.22(1), pp.62-62
- DOI
- 10.1186/s10194-021-01277-9
- PMID
- 34193048
- PMCID
- PMC8243868
- NLM abbreviation
- J Headache Pain
- ISSN
- 1129-2369
- eISSN
- 1129-2377
- Publisher
- Springer Milan
- Grant note
- R01 NS 075599 / ;
- Language
- English
- Date published
- 06/30/2021
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Craniofacial Anomalies Research Center
- Record Identifier
- 9984094983102771
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