Journal article
CLINICAL AND PATHOLOGICAL CHARACTERISTICS OF MICROPAPILLARY TRANSITIONAL CELL CARCINOMA: A HIGHLY AGGRESSIVE VARIANT
The Journal of urology, Vol.163(3), pp.748-751
03/2000
DOI: 10.1016/S0022-5347(05)67796-8
PMID: 10687969
Abstract
Purpose: We present preliminary clinical, histochemical and molecular findings for 5 patients with micropapillary transitional cell carcinoma of the bladder, a rare histological variant not widely recognized in the urological literature. Materials and Methods: The 5 patients were prospectively identified. In 3 cases immunohistochemical staining for expression of CD31, p53, E-cadherin, and α, β and γ-catenin was performed on paraffin embedded tissue. Sequencing was used to identify point mutations in exons 5 to 9 of p53, and exons 1 and 2 of H-ras. Results: Of the patients 2 died within 1 year of presentation to our institution with rapid local extension along the bladder serosal surface and ureteral sheaths. Another patient had progression to invasive disease within 22 months. In the 3 cases with immunohistochemical staining p53 was negative, despite positive staining of nonmicropapillary transitional cell carcinoma within the same specimen. Stains for the angiotrophic marker CD31 were negative. In all 3 cases normal membrane associated α, β and γ-catenin expression was present. Examination of p53 sequences revealed a single point mutation in exon 8 of 1 case. In 2 cases different mutations in exon 1 of H-ras were noted. Conclusions: Micropapillary transitional cell carcinoma is a rare and highly aggressive variant. Paradoxically, our study demonstrated no significant p53 abnormalities. The lacunar histological pattern did not appear to represent invasion of vascular spaces. Rather, these tumors seemed to have the ability to disrupt and replace the normal stromal matrix to achieve rapid nonendothelial extension. Thus, micropapillary histology may predict a lesser likelihood of surgical cure.
Details
- Title: Subtitle
- CLINICAL AND PATHOLOGICAL CHARACTERISTICS OF MICROPAPILLARY TRANSITIONAL CELL CARCINOMA: A HIGHLY AGGRESSIVE VARIANT
- Creators
- JODI K. Maranchie - Beth Israel Deaconess Medical CenterBOUTROS T. Bouyounes - Beth Israel Deaconess Medical CenterPING L. Zhang - Beth Israel Deaconess Medical CenterMICHAEL A. O’DONNELL - Beth Israel Deaconess Medical CenterIAN C. Summerhayes - Beth Israel Deaconess Medical CenterWILLIAM C. De WOLF - Beth Israel Deaconess Medical Center
- Resource Type
- Journal article
- Publication Details
- The Journal of urology, Vol.163(3), pp.748-751
- DOI
- 10.1016/S0022-5347(05)67796-8
- PMID
- 10687969
- ISSN
- 0022-5347
- eISSN
- 1527-3792
- Language
- English
- Date published
- 03/2000
- Academic Unit
- Urology
- Record Identifier
- 9984319984902771
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