CLINICOPATHOLOGICAL CORRELATION IN A PATIENT WITH PREVIOUSLY TREATED BIRDSHOT CHORIORETINOPATHY

Elliott H Sohn; Kathleen R Chirco; James C Folk; Robert F Mullins

doi:10.1097/ICB.0000000000000367

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CLINICOPATHOLOGICAL CORRELATION IN A PATIENT WITH PREVIOUSLY TREATED BIRDSHOT CHORIORETINOPATHY

Journal article

Open access

Peer reviewed

CLINICOPATHOLOGICAL CORRELATION IN A PATIENT WITH PREVIOUSLY TREATED BIRDSHOT CHORIORETINOPATHY

Elliott H Sohn, Kathleen R Chirco, James C Folk and Robert F Mullins

Retinal cases & brief reports, Vol.11(4), pp.344-347

2017

DOI: 10.1097/ICB.0000000000000367

PMCID: PMC5269553

PMID: 27465484

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https://www.ncbi.nlm.nih.gov/pmc/articles/5269553View

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Abstract

Birdshot chorioretinopathy (BCR) is a bilateral, chronic uveitis primarily involving the posterior segment that often results in progressive vision loss. Histopathology on eyes with BCR has been limited, but we had the rare opportunity to study the eyes of a donor with BCR. We sought to compare immunolabeling in the eyes of this donor who was treated with immunosuppression for over 30 years to age-matched controls. From each eye, a macular punch and superotemporal regions were used for cryostat sectioning, and immunohistochemistry was performed on the sections using antibodies directed against CD45, intercellular adhesion molecule-1, IBA1, and GFAP. The vasculature-binding lectin, Ulex europaeus agglutinin-I (UEA-I), was also used to perform lectin histochemistry. At death, her visual acuity was 20/25 right eye, 20/250 left eye with extensive chorioretinal atrophy, vascular attenuation, and disk pallor. Compared with controls, the BCR donor had extensive degeneration of the outer nuclear layer and retinal pigment epithelium as well as choroidal thinning with inner retinal preservation. Loss of UEA-I+ choroidal endothelial cells was extensive, and atypical intercellular adhesion molecule-1 labeling and IBA+ microglia/macrophages were present along with widespread GFAP labeling throughout the retina. The BCR may cause progressive chorioretinal and optic atrophy with long-standing increased leukocyte abundance throughout the retina and microglial activation especially at the retina-choroid interface.

Chorioretinitis - pathology

Humans

Adult

Female

Choroid - pathology

Retina - pathology

Cadaver

Details

Title: Subtitle: CLINICOPATHOLOGICAL CORRELATION IN A PATIENT WITH PREVIOUSLY TREATED BIRDSHOT CHORIORETINOPATHY
Creators: Elliott H Sohn - Department of Ophthalmology and Visual Sciences, Stephen A. Wynn Institute for Vision Research, University of Iowa, Iowa City, Iowa
Kathleen R Chirco
James C Folk
Robert F Mullins
Resource Type: Journal article
Publication Details: Retinal cases & brief reports, Vol.11(4), pp.344-347
DOI: 10.1097/ICB.0000000000000367
PMID: 27465484
PMCID: PMC5269553
NLM abbreviation: Retin Cases Brief Rep
ISSN: 1937-1578
eISSN: 1937-1578
Publisher: United States
Grant note: R01 EY024605 / NEI NIH HHS
Language: English
Date published: 2017
Academic Unit: Ophthalmology and Visual Sciences
Record Identifier: 9983979964302771

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