CO2 exposure as translational cross-species experimental model for panic

N K Leibold; D L A van den Hove; W Viechtbauer; G F Buchanan; L Goossens; I Lange; I Knuts; K P Lesch; H W M Steinbusch; K R J Schruers

doi:10.1038/tp.2016.162

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CO2 exposure as translational cross-species experimental model for panic

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CO2 exposure as translational cross-species experimental model for panic

N K Leibold, D L A van den Hove, W Viechtbauer, G F Buchanan, L Goossens, I Lange, I Knuts, K P Lesch, H W M Steinbusch and K R J Schruers

Translational psychiatry, Vol.6(9), pp.e885-e885

09/2016

DOI: 10.1038/tp.2016.162

PMCID: PMC5048202

PMID: 27598969

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Abstract

The current diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders are being challenged by the heterogeneity and the symptom overlap of psychiatric disorders. Therefore, a framework toward a more etiology-based classification has been initiated by the US National Institute of Mental Health, the research domain criteria project. The basic neurobiology of human psychiatric disorders is often studied in rodent models. However, the differences in outcome measurements hamper the translation of knowledge. Here, we aimed to present a translational panic model by using the same stimulus and by quantitatively comparing the same outcome measurements in rodents, healthy human subjects and panic disorder patients within one large project. We measured the behavioral–emotional and bodily response to CO 2 exposure in all three samples, allowing for a reliable cross-species comparison. We show that CO 2 exposure causes a robust fear response in terms of behavior in mice and panic symptom ratings in healthy volunteers and panic disorder patients. To improve comparability, we next assessed the respiratory and cardiovascular response to CO 2 , demonstrating corresponding respiratory and cardiovascular effects across both species. This project bridges the gap between basic and human research to improve the translation of knowledge between these disciplines. This will allow significant progress in unraveling the etiological basis of panic disorder and will be highly beneficial for refining the diagnostic categories as well as treatment strategies.

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Title: Subtitle: CO2 exposure as translational cross-species experimental model for panic
Creators: N K Leibold - , Maastricht
D L A van den Hove - , Maastricht
W Viechtbauer - , Maastricht
G F Buchanan - , New Haven, CT
L Goossens - , Maastricht
I Lange - , Maastricht
I Knuts - , Maastricht
K P Lesch - , Maastricht
H W M Steinbusch - , Maastricht
K R J Schruers - , Maastricht
Resource Type: Journal article
Publication Details: Translational psychiatry, Vol.6(9), pp.e885-e885
DOI: 10.1038/tp.2016.162
PMID: 27598969
PMCID: PMC5048202
NLM abbreviation: Transl Psychiatry
ISSN: 2158-3188
eISSN: 2158-3188
Publisher: Nature Publishing Group
Alternative title: CO2 exposure as translational model for panic
Language: English
Date published: 09/2016
Academic Unit: Neurology; Iowa Neuroscience Institute
Record Identifier: 9984015359802771

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