COMT Val158Met Polymorphism and Executive Functions in Obsessive-Compulsive Disorder

Raşit TÜKEL; Hakan GÜRVIT; Nalan ÖZTÜRK; Berna ÖZATA; Banu Aslantas Ertekin; Erhan ERTEKIN; Bengi BARAN; Şükriye Akça Kalem; Deniz BÜYÜKGÖK; Güher Saruhan Direskeneli

doi:10.1176/appi.neuropsych.12040103

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COMT Val158Met Polymorphism and Executive Functions in Obsessive-Compulsive Disorder

Journal article

Open access

Peer reviewed

COMT Val158Met Polymorphism and Executive Functions in Obsessive-Compulsive Disorder

Raşit TÜKEL, Hakan GÜRVIT, Nalan ÖZTÜRK, Berna ÖZATA, Banu Aslantas Ertekin, Erhan ERTEKIN, Bengi BARAN, Şükriye Akça Kalem, Deniz BÜYÜKGÖK and Güher Saruhan Direskeneli

The journal of neuropsychiatry and clinical neurosciences, Vol.25(3), pp.214-221

2013

DOI: 10.1176/appi.neuropsych.12040103

PMID: 23774999

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Abstract

This study investigated the association between the catechol-O-methyl transferase (COMT) Val158Met polymorphism and executive functions in 101 patients with obsessive-compulsive disorder (OCD) and 100 healthy-control subjects (HS). Results showed that there was no significant difference for the genotype distributions between the OCD and HS groups. OCD-Met carrier subgroup's TMT B-A difference and lexical fluency scores were found to be significantly poorer than both HS subgroups. These findings suggest that lower activity of COMT associated with the Met allele, leading to higher levels of dopamine in the prefrontal cortex, lead to poorer executive function in OCD.

Anxiety disorders. Neuroses

Psychology. Psychoanalysis. Psychiatry

Adult and adolescent clinical studies

Psychopathology. Psychiatry

Biological and medical sciences

Medical sciences

Obsessive-compulsive disorders

Details

Title: Subtitle: COMT Val158Met Polymorphism and Executive Functions in Obsessive-Compulsive Disorder
Creators: Raşit TÜKEL - Istanbul Faculty of Medicine, Department of Psychiatry, Istanbul University, Istanbul, Turkey
Hakan GÜRVIT - Dept. of Neurology, Behavioral Neurology, and Movement Disorders Unit, Istanbul University, Istanbul, Turkey
Nalan ÖZTÜRK - Istanbul Faculty of Medicine, Department of Psychiatry, Istanbul University, Istanbul, Turkey
Berna ÖZATA - Istanbul Faculty of Medicine, Department of Psychiatry, Istanbul University, Istanbul, Turkey
Banu Aslantas Ertekin - Istanbul Faculty of Medicine, Department of Psychiatry, Istanbul University, Istanbul, Turkey
Erhan ERTEKIN - Istanbul Faculty of Medicine, Department of Psychiatry, Istanbul University, Istanbul, Turkey
Bengi BARAN - Dept. of Neurology, Behavioral Neurology, and Movement Disorders Unit, Istanbul University, Istanbul, Turkey
Şükriye Akça Kalem - Dept. of Neurology, Behavioral Neurology, and Movement Disorders Unit, Istanbul University, Istanbul, Turkey
Deniz BÜYÜKGÖK - Istanbul Faculty of Medicine, Department of Psychiatry, Istanbul University, Istanbul, Turkey
Güher Saruhan Direskeneli - Dept. of Physiology, Istanbul University, Istanbul, Turkey
Resource Type: Journal article
Publication Details: The journal of neuropsychiatry and clinical neurosciences, Vol.25(3), pp.214-221
DOI: 10.1176/appi.neuropsych.12040103
PMID: 23774999
NLM abbreviation: J Neuropsychiatry Clin Neurosci
ISSN: 0895-0172
eISSN: 1545-7222
Publisher: American Psychiatric Publishing; Arlington, VA
Language: English
Date published: 2013
Academic Unit: Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984065475402771

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