CORRELATION OF ABDOMINAL rSO2 WITH SUPERIOR MESENTERIC ARTERY VELOCITIES IN PRETERM INFANTS

Maria Gillam-Krakauer; Caitlin M Cochran; James C Slaughter; Sruthi Polavarapu; Steven J McElroy; Marta Hernanz-Schulman; Barbara Engelhardt

doi:10.1038/jp.2013.3

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CORRELATION OF ABDOMINAL rSO2 WITH SUPERIOR MESENTERIC ARTERY VELOCITIES IN PRETERM INFANTS

Journal article

Peer reviewed

CORRELATION OF ABDOMINAL rSO2 WITH SUPERIOR MESENTERIC ARTERY VELOCITIES IN PRETERM INFANTS

Maria Gillam-Krakauer, Caitlin M Cochran, James C Slaughter, Sruthi Polavarapu, Steven J McElroy, Marta Hernanz-Schulman and Barbara Engelhardt

Journal of perinatology, Vol.33(8), pp.609-612

08/2013

DOI: 10.1038/jp.2013.3

PMCID: PMC3655136

PMID: 23392317

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Abstract

Objective: Near-infrared spectroscopy (NIRS) is used to monitor brain and kidney perfusion in at-risk premature and term neonates. Although NIRS holds potential for bedside monitoring of intestinal perfusion, there is insufficient evidence showing correlation with mesenteric blood flow. To determine if an association exists between abdominal regional oxygen saturation (A-rSO2) and mesenteric blood flow, we compared changes in A-rSO2 to changes in blood flow velocity in the superior mesenteric artery (SMA) before and after feedings in very-low birthweight infants. Study design: A-rSO2 was continuously monitored midline below the umbilicus for 3 days in 18 stable 25 to 31 week bolus-fed infants (median BW 1203 g, median age 5 days). We compared change in SMA velocity from immediately before to 10 min and 60 to 120 min after feeding with change in A-rSO2 over the same time. Spearman's rank correlation was used to ascertain if a significant association existed. Result: Change in A-rSO2 was significantly associated with change in systolic, diastolic, and mean SMA velocity from fasting to 60 to 120 min after feeding (P=0.016, 0.021, 0.010) and from 10 min after a feed to 60 to 120 min after feeding (P=0.009, 0.035, 0.032). Conclusion: In very preterm infants, A-rSO2 reflects blood flow in the SMA and can provide non-invasive continuous monitoring of intestinal perfusion. Further studies are indicated to determine the sensitivity of NIRS to detect early intestinal pathology in this population.

very-low birthweight

near-infrared spectroscopy

premature

splanchnic

mesenteric

Details

Title: Subtitle: CORRELATION OF ABDOMINAL rSO2 WITH SUPERIOR MESENTERIC ARTERY VELOCITIES IN PRETERM INFANTS
Creators: Maria Gillam-Krakauer - Assistant Professor of Pediatrics, Division of Neonatology, Monroe Carell Jr. Children’s Hospital at Vanderbilt, Nashville, TN
Caitlin M Cochran - Sonography Supervisor, Department of Radiology, Monroe Carell Jr. Children’s Hospital at Vanderbilt, Nashville, TN
James C Slaughter - Assistant Professor, Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN
Sruthi Polavarapu - Research Fellow, Division of Neonatology, Monroe Carell Jr. Children’s Hospital at Vanderbilt, Nashville, TN
Steven J McElroy - Assistant Professor of Pediatrics, Division of Neonatology, University of Iowa, Iowa City, IA
Marta Hernanz-Schulman - Professor, Departments of Radiology and Pediatrics, Radiology Vice-Chair in Pediatrics Medical Director, Diagnostic Imaging, Monroe Carell Jr. Children’s Hospital at Vanderbilt, Nashville, TN
Barbara Engelhardt - Associate Professor of Pediatrics, Division of Neonatology, Monroe Carell Jr. Children’s Hospital at Vanderbilt, Nashville, TN
Resource Type: Journal article
Publication Details: Journal of perinatology, Vol.33(8), pp.609-612
DOI: 10.1038/jp.2013.3
PMID: 23392317
PMCID: PMC3655136
NLM abbreviation: J Perinatol
ISSN: 0743-8346
eISSN: 1476-5543
Language: English
Date published: 08/2013
Academic Unit: Microbiology and Immunology; Stead Family Department of Pediatrics
Record Identifier: 9984093219202771

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