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COVID-19 and Diabetes Mellitus: A Complex Interplay
Journal article   Open access   Peer reviewed

COVID-19 and Diabetes Mellitus: A Complex Interplay

Gopala Koneru, Hager H. Sayed, Nayera A. Abd-elhamed, Nouran Elsedfy, Amira H. Mohamed, Hania A. Abdellatif, Fatmaalzharaa F. Mohamed, Esraa H. Bahnasawy, Nayera K. Mousa, Aml Eisa, …
Journal of pure & applied microbiology : an international research journal of microbiology, Vol.15(2), pp.512-523
06/01/2021
DOI: 10.22207/JPAM.15.2.16
url
https://doi.org/10.22207/JPAM.15.2.16View
Published (Version of record) Open Access

Abstract

COVID-19 pandemic, which caused by the newly emerged severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), puts the entire world in an unprecedented crisis, leaving behind huge human losses and serious socio-economical damages. The clinical spectrum of COVID-19 varies from asymptomatic to multi-organ manifestations. Diabetes mellitus (DM) is a chronic inflammatory condition, which associated with metabolic and vascular abnormalities, increases the risk for SARSCoV-2 infection, severity and mortality. Due to global prevalence, DM effect on COVID-19 outcomes as well as the potential mechanisms by which DM modulates the host-viral interactions and host-immune responses are discussed in this review. This review also highlights the effects of anti-diabetic drugs on treatment of SARS-CoV-2 infection and vice versa.
Microbiology Biotechnology & Applied Microbiology Life Sciences & Biomedicine Science & Technology

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