Journal article
COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study
Infection, Vol.49(5), pp.889-905
06/25/2021
DOI: 10.1007/s15010-021-01599-5
PMCID: PMC8231091
PMID: 34170486
Abstract
Abstract Background The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men.
Details
- Title: Subtitle
- COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study
- Creators
- Sheryl AbdukahilAli Ait Hssain - University of OxfordYounes Tamlihat - University of OxfordKazali Alidjnou - University of OxfordCarlos de BritoJean Assie - University of OxfordDiego RinconFelwa HumaidHans Bosse - University of OxfordJose CalvacheFrançois CarrierGiulio CavalliMatthew ChengHwa ChoSung ChoJose CidadeJose HerrerosBarbara CitarellaSebastiano ColomboArianne CorpuzCharles D’orleansRafael de Oliveira FrançaSanti DewayantiJuan DiazJames DouglasEmanuele MangoniAnne Dyrhol-RiiseJosé VidalMohammed SanharawiAnna EverdingArie FatoniEglantine DevougeLetizia FlorioClaudio FonsecaMarcela FreireAna Freitas RibeiroElena CurtoLouis MorlaesEdward GrandinDomenico GriecoAnja LordemannAntonia HoJan HolterJuan HorcajadaCarmen DominguezRuth SotomayorRuth GarcíaDarshana KandambySimreen JohalAnders KildalGry BekkenMalte VasconcelosPavan VechamEka LantangMarta SantosSu LeeGianluigi BassiWei LimJean LucetKarl MüllerJuan SanchezLars MaierCeila SantCharbel EidCelina MartelliCaroline RegoEva MarwaliJuan JimenezHugo MaldonadoDiego TutilloClara PerrotDimitra MyrodiaPauline NgWing NgOrna ChoileainBudha OinamAna OliveiraClaudia Orozco-ChamorroPrasan PandaLuis ReyesAna RiosMaria NuñezJulia AbreuAleksander HoltenXavier ChoezHoi ShumNassima MohammedMaria SilvaWai SinMyung SongMaria UvaMagdalena SvistunovDuong ThuyBharath VijayaraghavanRosario Santos-OlmoHuynh TrieuJoy VillanuevaRyuzo AbeLaurent Abel - Human genetics of infectious diseases: Complex predispositionISARIC Clinical Characterisation Group
- Contributors
- Lovkesh Arora (Contributor) - University of Iowa, Anesthesia
- Resource Type
- Journal article
- Publication Details
- Infection, Vol.49(5), pp.889-905
- DOI
- 10.1007/s15010-021-01599-5
- PMID
- 34170486
- PMCID
- PMC8231091
- NLM abbreviation
- Infection
- ISSN
- 0300-8126
- eISSN
- 1439-0973
- Publisher
- Springer Verlag
- Language
- English
- Date published
- 06/25/2021
- Academic Unit
- Anesthesia
- Record Identifier
- 9984296148902771
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