CT-Based Characterization of Transverse and Longitudinal Trabeculae and Its Applications

Xiaoliu Zhang; Elena M Letuchy; Steven M Levy; James C Torner; Punam K Saha

doi:10.1117/12.2549881

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Journal article

CT-Based Characterization of Transverse and Longitudinal Trabeculae and Its Applications

Xiaoliu Zhang, Elena M Letuchy, Steven M Levy, James C Torner and Punam K Saha

Proceedings of SPIE, the international society for optical engineering, Vol.11317, 113171F

02/2020

DOI: 10.1117/12.2549881

PMID: 32201451

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Abstract

Osteoporosis is a common age-related disease characterized by reduced bone mineral density (BMD), micro-structural deterioration, and enhanced fracture-risk. Although, BMD is clinically used to define osteoporosis, there are compelling evidences that bone micro-structural properties are strong determinants of bone strength and fracture-risk. Reliable measures of effective trabecular bone (Tb) micro-structural features are of paramount clinical significance. Tb consists of transverse and longitudinal micro-structures, and there is a hypothesis that transverse trabeculae improve bone strength by arresting buckling of longitudinal trabeculae. In this paper, we present an emerging clinical CT-based new method for characterizing transverse and longitudinal trabeculae, validate the method, and examine its application in human studies. Specifically, we examine repeat CT scan reproducibility, and evaluate the relationships of these measures with gender and body size using human CT data from the Iowa Bone Development Study (IBDS) (n = 99; 49 female). Based on a cadaveric ankle study (n = 12), both transverse and longitudinal Tb measures are found reproducible (ICC > 0.94). It was observed in the IBDS human data that males have significantly higher trabecular bone measures than females for both inner (p < 0.05) and outer (p < 0.01) regions of interest (ROIs). For weight, Spearman correlations ranged 0.43-0.48 for inner ROI measures and 0.50-0.52 for outer ROI measures for females versus 0.30-0.34 and 0.23-0.25 for males. Correlation with height was lower (0.36-0.39), but still mostly significant for females. No association of trabecular measures with height was found for males.

Osteoporosis

Topology

CT imaging

longitudinal trabeculae

micro-structure

orientation

trabecular bone

transverse trabeculae

Details

Title: Subtitle: CT-Based Characterization of Transverse and Longitudinal Trabeculae and Its Applications
Creators: Xiaoliu Zhang - University of Iowa
Elena M Letuchy - University of Iowa
Steven M Levy - University of Iowa
James C Torner - University of Iowa
Punam K Saha - University of Iowa
Resource Type: Journal article
Publication Details: Proceedings of SPIE, the international society for optical engineering, Vol.11317, 113171F
DOI: 10.1117/12.2549881
PMID: 32201451
NLM abbreviation: Proc SPIE Int Soc Opt Eng
ISSN: 0277-786X
eISSN: 1996-756X
Language: English
Date published: 02/2020
Academic Unit: Preventive and Community Dentistry; Radiology; Electrical and Computer Engineering; Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
Record Identifier: 9984197915802771

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