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CT-based assessment of regional pulmonary microvascular blood flow parameters
Journal article   Open access   Peer reviewed

CT-based assessment of regional pulmonary microvascular blood flow parameters

Chulho Won, Deokiee Chon, Jehangir Tajik, Binh Tran, G Blake Robinswood, Kenneth C Beck and Eric A Hoffman
Journal of applied physiology (1985), Vol.94(6), pp.2483-2493
06/01/2003
DOI: 10.1152/japplphysiol.00688.2002
PMID: 12588787
url
https://doi.org/10.1152/japplphysiol.00688.2002View
Published (Version of record) Open Access

Abstract

To determine regional pulmonary microvascular mean transit times (MTTs), we used electrocardiogram-gated X-ray computed tomographic imaging to follow bolus radiopaque contrast material through the lungs in anesthetized animals (7 dogs and 1 pig, prone and supine). By deconvolution/reconvolution of regional time-attenuation curves obtained from parenchyma and large lobar arteries, we estimated the microvascular residue function and reconstituted the regional microvascular time-attenuation curves and, thus, regional microvascular MTTs. The mean microvascular MTTs in the supine and prone postures were 3.94 +/- 1.0 and 3.40 +/- 0.84 (mean +/- SD), respectively. The dependent-nondependent vertical gradient of MTT was greater in the supine [slope = 0.25 +/- 0.10 (SD), P < 0.001 by t-test] than in the prone (_0.03 +/- 0.06 in 6 of 8 animals; 2 outliers had positive slopes) posture. In both postures, there was a trend toward faster transit times in the dorsal-basal lung region in six of the eight animals, suggesting gravity-independent higher vascular conductance dorsocaudally. We conclude that deconvolution methods, in association with electrocardiogram-gated high-speed X-ray computed tomography, can provide insights into regional heterogeneity of pulmonary microvascular MTT in vivo. [PUBLICATION ABSTRACT]
 Medical Imaging Blood vessels Lungs Tomography

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