Journal article
CT-based texture analysis potentially provides prognostic information complementary to interim fdg-pet for patients with hodgkin's and aggressive non-hodgkin's lymphomas
European radiology, Vol.27(3), pp.1012-1020
03/01/2017
DOI: 10.1007/s00330-016-4470-8
PMCID: PMC5306313
PMID: 27380902
Abstract
The purpose of this study was to investigate the ability of computed tomography texture analysis (CTTA) to provide additional prognostic information in patients with Hodgkin's lymphoma (HL) and high-grade non-Hodgkin's lymphoma (NHL).
This retrospective, pilot-study approved by the IRB comprised 45 lymphoma patients undergoing routine 18F-FDG-PET-CT. Progression-free survival (PFS) was determined from clinical follow-up (mean-duration: 40 months; range: 10-62 months). Non-contrast-enhanced low-dose CT images were submitted to CTTA comprising image filtration to highlight features of different sizes followed by histogram-analysis using kurtosis. Prognostic value of CTTA was compared to PET FDG-uptake value, tumour-stage, tumour-bulk, lymphoma-type, treatment-regime, and interim FDG-PET (iPET) status using Kaplan-Meier analysis. Cox regression analysis determined the independence of significantly prognostic imaging and clinical features.
A total of 27 patients had aggressive NHL and 18 had HL. Mean PFS was 48.5 months. There was no significant difference in pre-treatment CTTA between the lymphoma sub-types. Kaplan-Meier analysis found pre-treatment CTTA (medium feature scale, p=0.010) and iPET status (p < 0.001) to be significant predictors of PFS. Cox analysis revealed that an interaction between pre-treatment CTTA and iPET status was the only independent predictor of PFS (HR: 25.5, 95% CI: 5.4-120, p < 0.001). Specifically, pre-treatment CTTA risk stratified patients with negative iPET.
CTTA can potentially provide prognostic information complementary to iPET for patients with HL and aggressive NHL.
CT texture-analysis (CTTA) provides prognostic information complementary to interim FDG-PET in Lymphoma.
Pre-treatment CTTA and interim PET status were significant predictors of progression-free survival.
Patients with negative interim PET could be further stratified by pre-treatment CTTA.
Provide precision surveillance where additional imaging reserved for patients at greatest recurrence-risk.
Assists in risk-adapted treatment strategy based on interim PET and CTTA.
Details
- Title: Subtitle
- CT-based texture analysis potentially provides prognostic information complementary to interim fdg-pet for patients with hodgkin's and aggressive non-hodgkin's lymphomas
- Creators
- B. Ganeshan - University College LondonK. A. Miles - University College LondonS. Babikir - International Atomic Energy AgencyR. Shortman - University College LondonA. Afaq - University College LondonK. M. Ardeshna - University College LondonA. M. Groves - University College LondonI. Kayani - University College London
- Resource Type
- Journal article
- Publication Details
- European radiology, Vol.27(3), pp.1012-1020
- DOI
- 10.1007/s00330-016-4470-8
- PMID
- 27380902
- PMCID
- PMC5306313
- NLM abbreviation
- Eur Radiol
- ISSN
- 0938-7994
- eISSN
- 1432-1084
- Publisher
- Springer Nature
- Number of pages
- 9
- Grant note
- NIHR; National Institute for Health Research (NIHR) 16463 / Cancer Research UK UK's Department of Health's NIHR Biomedical Research Centre's; National Institute for Health Research (NIHR)
- Language
- English
- Date published
- 03/01/2017
- Academic Unit
- Radiology
- Record Identifier
- 9984318814302771
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