CT-derived 3D-diaphragm motion in emphysema and IPF compared to normal subjects

Ji Hee Kang; Jiwoong Choi; Kum Ju Chae; Kyung Min Shin; Chang-Hoon Lee; Junfeng Guo; Ching-Long Lin; Eric A Hoffman; Changhyun Lee

doi:10.1038/s41598-021-93980-5

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CT-derived 3D-diaphragm motion in emphysema and IPF compared to normal subjects

Journal article

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CT-derived 3D-diaphragm motion in emphysema and IPF compared to normal subjects

Ji Hee Kang, Jiwoong Choi, Kum Ju Chae, Kyung Min Shin, Chang-Hoon Lee, Junfeng Guo, Ching-Long Lin, Eric A Hoffman and Changhyun Lee

Scientific reports, Vol.11(1), pp.14923-14923

07/21/2021

DOI: 10.1038/s41598-021-93980-5

PMCID: PMC8295260

PMID: 34290275

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Abstract

Image registration-based local displacement analysis enables evaluation of respiratory motion between two computed tomography-captured lung volumes. The objective of this study was to compare diaphragm movement among emphysema, idiopathic pulmonary fibrosis (IPF) and normal subjects. 29 normal, 50 emphysema, and 51 IPF subjects were included. A mass preserving image registration technique was used to compute displacement vectors of local lung regions at an acinar scale. Movement of the diaphragm was assumed to be equivalent to movement of the basal lung within 5 mm from the diaphragm. Magnitudes and directions of displacement vectors were compared between the groups. Three-dimensional (3D) and apico-basal displacements were smaller in emphysema than normal subjects (P = 0.003, P = 0.002). Low lung attenuation area on expiration scan showed significant correlations with decreased 3D and apico-basal displacements (r = − 0.546, P < 0.0001; r = − 0.521, P < 0.0001) in emphysema patients. Dorsal–ventral displacement was smaller in IPF than normal subjects (P < 0.0001). The standard deviation of the displacement angle was greater in both emphysema and IPF patients than normal subjects (P < 0.0001). In conclusion, apico-basal movement of the diaphragm is reduced in emphysema while dorsal–ventral movement is reduced in IPF. Image registration technique to multi-volume CT scans provides insight into the pathophysiology of limited diaphragmatic motion in emphysema and IPF.

Biological physics

Computational biophysics

Respiratory tract diseases

Details

Title: Subtitle: CT-derived 3D-diaphragm motion in emphysema and IPF compared to normal subjects
Creators: Ji Hee Kang - Konkuk University
Jiwoong Choi - University of Kansas
Kum Ju Chae - Jeonbuk National University
Kyung Min Shin - Kyungpook National University
Chang-Hoon Lee - Seoul National University Hospital
Junfeng Guo - University of Iowa
Ching-Long Lin - Iowa City, IA USA
Eric A Hoffman - University of Iowa
Changhyun Lee - Iowa City, IA USA
Resource Type: Journal article
Publication Details: Scientific reports, Vol.11(1), pp.14923-14923
DOI: 10.1038/s41598-021-93980-5
PMID: 34290275
PMCID: PMC8295260
NLM abbreviation: Sci Rep
ISSN: 2045-2322
eISSN: 2045-2322
Publisher: Nature Publishing Group UK
Grant note: 2018001360001 / ; 2017R1D1A1A09082160 / ;
Language: English
Date published: 07/21/2021
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Mechanical Engineering; Internal Medicine
Record Identifier: 9984196557502771

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