CT-derived vessel segmentation for analysis of post-radiation therapy changes in vasculature and perfusion

Antonia E Wuschner; Mattison J Flakus; Eric M Wallat; Joseph M Reinhardt; Dhanansayan Shanmuganayagam; Gary E Christensen; Sarah E Gerard; John E Bayouth

doi:10.3389/fphys.2022.1008526

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CT-derived vessel segmentation for analysis of post-radiation therapy changes in vasculature and perfusion

Journal article

Open access

Peer reviewed

CT-derived vessel segmentation for analysis of post-radiation therapy changes in vasculature and perfusion

Antonia E Wuschner, Mattison J Flakus, Eric M Wallat, Joseph M Reinhardt, Dhanansayan Shanmuganayagam, Gary E Christensen, Sarah E Gerard and John E Bayouth

Frontiers in physiology, Vol.13, 1008526

10/17/2022

DOI: 10.3389/fphys.2022.1008526

PMCID: PMC9619090

PMID: 36324304

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Abstract

Vessel segmentation in the lung is an ongoing challenge. While many methods have been able to successfully identify vessels in normal, healthy, lungs, these methods struggle in the presence of abnormalities. Following radiotherapy, these methods tend to identify regions of radiographic change due to post-radiation therapytoxicities as vasculature falsely. By combining texture analysis and existing vasculature and masking techniques, we have developed a novel vasculature segmentation workflow that improves specificity in irradiated lung while preserving the sensitivity of detection in the rest of the lung. Furthermore, radiation dose has been shown to cause vascular injury as well as reduce pulmonary function post-RT. This work shows the improvements our novel vascular segmentation method provides relative to existing methods. Additionally, we use this workflow to show a dose dependent radiation-induced change in vasculature which is correlated with previously measured perfusion changes (R2 = 0.72) in both directly irradiated and indirectly damaged regions of perfusion. These results present an opportunity to extend non-contrast CT-derived models of functional change following radiation therapy.

ct-derived perfusion

lung perfusion

post-RT vascular change

pulmonary vasculature segmentation

radiation-induced damage

Details

Title: Subtitle: CT-derived vessel segmentation for analysis of post-radiation therapy changes in vasculature and perfusion
Creators: Antonia E Wuschner - Department of Medical Physics, University of Wisconsin, Madison, WI, United States
Mattison J Flakus - Department of Medical Physics, University of Wisconsin, Madison, WI, United States
Eric M Wallat - Department of Medical Physics, University of Wisconsin, Madison, WI, United States
Joseph M Reinhardt - Roy J. Carver Department of Biomedical Engineering, University of Iowa, Iowa, IA, United States
Dhanansayan Shanmuganayagam - Department of Animal Science, University of Wisconsin, Madison, WI, United States
Gary E Christensen - Department of Electrical and Computer Engineering, University of Iowa, Iowa, IA, United States
Sarah E Gerard
John E Bayouth - Department of Radiation Medicine, Oregon Health Sciences University, Portland, OR, United States
Resource Type: Journal article
Publication Details: Frontiers in physiology, Vol.13, 1008526
DOI: 10.3389/fphys.2022.1008526
PMID: 36324304
PMCID: PMC9619090
NLM abbreviation: Front Physiol
ISSN: 1664-042X
eISSN: 1664-042X
Publisher: Frontiers Media S.A
Grant note: DOI: 10.13039/100000002, name: National Institutes of Health, award: CA166703
Language: English
Date published: 10/17/2022
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Radiation Oncology; Radiation Research Laboratory; The Iowa Institute for Biomedical Imaging; Advanced Pulmonary Physiomic Imaging Laboratory; Holden Comprehensive Cancer Center
Record Identifier: 9984304549702771

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