Journal article
CT metrics of airway disease and emphysema in severe COPD
Chest, Vol.136(2), pp.396-404
08/2009
DOI: 10.1378/chest.08-2858
PMCID: PMC2733947
PMID: 19411295
Abstract
CT scan measures of emphysema and airway disease have been correlated with lung function in cohorts of subjects with a range of COPD severity. The contribution of CT scan-assessed airway disease to objective measures of lung function and respiratory symptoms such as dyspnea in severe emphysema is less clear.
Using data from 338 subjects in the National Emphysema Treatment Trial (NETT) Genetics Ancillary Study, densitometric measures of emphysema using a threshold of -950 Hounsfield units (%LAA-950) and airway wall phenotypes of the wall thickness (WT) and the square root of wall area (SRWA) of a 10-mm luminal perimeter airway were calculated for each subject. Linear regression analysis was performed for outcome variables FEV(1) and percent predicted value of FEV(1) with CT scan measures of emphysema and airway disease.
In univariate analysis, there were significant negative correlations between %LAA-950 and both the WT (r = -0.28, p = 0.0001) and SRWA (r = -0.19, p = 0.0008). Airway wall thickness was weakly but significantly correlated with postbronchodilator FEV(1)% predicted (R = -0.12, p = 0.02). Multivariate analysis showed significant associations between either WT or SRWA (beta = -5.2, p = 0.009; beta = -2.6, p = 0.008, respectively) and %LAA-950 (beta = -10.6, p = 0.03) with the postbronchodilator FEV(1)% predicted. Male subjects exhibited significantly thicker airway wall phenotypes (p = 0.007 for WT and p = 0.0006 for SRWA).
Airway disease and emphysema detected by CT scanning are inversely related in patients with severe COPD. Airway wall phenotypes were influenced by gender and associated with lung function in subjects with severe emphysema.
Details
- Title: Subtitle
- CT metrics of airway disease and emphysema in severe COPD
- Creators
- Woo Jin Kim - Kangwon National UniversityEdwin K Silverman - Harvard UniversityEric Hoffman - University of IowaGerard J Criner - Temple UniversityZab Mosenifar - Cedars-Sinai Medical CenterFrank C Sciurba - University of PittsburghBarry J Make - National Jewish HealthVincent Carey - Harvard UniversityRaúl San José Estépar - Brigham and Women's HospitalAlejandro Diaz - Harvard UniversityJohn J Reilly - University of PittsburghFernando J Martinez - University of MichiganGeorge R Washko - Harvard UniversityNETT Research Group
- Resource Type
- Journal article
- Publication Details
- Chest, Vol.136(2), pp.396-404
- DOI
- 10.1378/chest.08-2858
- PMID
- 19411295
- PMCID
- PMC2733947
- ISSN
- 0012-3692
- eISSN
- 1931-3543
- Grant note
- N01HR76103 / NHLBI NIH HHS N01HR76119 / NHLBI NIH HHS K25 HL104085 / NHLBI NIH HHS N01HR76107 / NHLBI NIH HHS N01HR76111 / NHLBI NIH HHS K23 HL089353 / NHLBI NIH HHS N01HR76114 / NHLBI NIH HHS N01HR76102 / NHLBI NIH HHS N01HR76104 / NHLBI NIH HHS N01HR76116 / NHLBI NIH HHS N01HR76110 / NHLBI NIH HHS N01HR76108 / NHLBI NIH HHS N01 HR076115 / NHLBI NIH HHS N01HR76105 / NHLBI NIH HHS 1K23HL089353-01A1 / NHLBI NIH HHS N01HR76113 / NHLBI NIH HHS N01HR76109 / NHLBI NIH HHS N01HR76101 / NHLBI NIH HHS N01HR76118 / NHLBI NIH HHS N01HR76106 / NHLBI NIH HHS N01HR76112 / NHLBI NIH HHS
- Language
- English
- Date published
- 08/2009
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984196976402771
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