CUPpling calcium to lysosomal biogenesis

Robert C Piper; J Paul Luzio

doi:10.1016/j.tcb.2004.07.010

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CUPpling calcium to lysosomal biogenesis

Journal article

Peer reviewed

CUPpling calcium to lysosomal biogenesis

Robert C Piper and J Paul Luzio

Trends in cell biology, Vol.14(9), pp.471-473

09/2004

DOI: 10.1016/j.tcb.2004.07.010

PMID: 15350973

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Abstract

Transport from late endosomes to lysosomes results in the formation of an endosome-lysosome hybrid organelle from which late endosomes and lysosomes must be re-formed. Recent studies indicate that the transient receptor potential (TRP)-related channel mucolipin-1 (the loss of which causes mucolipidosis type IV) and its Caenorhabditis elegans orthologue CUP-5 might control the process of lysosome re-formation by regulating calcium flux.

Animals

Biological Transport

Caenorhabditis elegans - physiology

Caenorhabditis elegans Proteins - chemistry

Caenorhabditis elegans Proteins - physiology

Calcium - metabolism

Endosomes - physiology

Lysosomes - metabolism

Lysosomes - physiology

Membrane Proteins - chemistry

Membrane Proteins - metabolism

Membrane Proteins - physiology

Models, Biological

Transient Receptor Potential Channels

TRPM Cation Channels

Details

Title: Subtitle: CUPpling calcium to lysosomal biogenesis
Creators: Robert C Piper - University of Iowa
J Paul Luzio - University of Cambridge
Resource Type: Journal article
Publication Details: Trends in cell biology, Vol.14(9), pp.471-473
DOI: 10.1016/j.tcb.2004.07.010
PMID: 15350973
ISSN: 0962-8924
eISSN: 1879-3088
Grant note: R01 GM058202 / NIGMS NIH HHS
Language: English
Date published: 09/2004
Academic Unit: Molecular Physiology and Biophysics; Medicine Administration; Internal Medicine
Record Identifier: 9984297504502771

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