Journal article
CYP2C92 is associated with indomethacin treatment failure for patent ductus arteriosus
Pharmacogenomics, Vol.20(13), pp.939-946
08/2019
DOI: 10.2217/pgs-2019-0079
PMCID: PMC6817966
PMID: 31486736
Abstract
Aims: To identify clinical andgenetic factors associated with indomethacin treatment failure in preterm neonates with patent ductus arteriosus (PDA). Patients & Methods: This is a multicenter cohort study of 144 preterm infants (22–32 weeks gestational age) at three centers who received at least one treatment course of indomethacin for PDA. Indomethacin failure was defined as requiring subsequent surgical intervention. Results: In multivariate analysis, gestational age (AOR 0.76, 95% CI 0.60–0.96), surfactant use (AOR 9.77, 95% CI 1.15–83.26), and CYP2C9*2 (AOR 3.74; 95% CI 1.34–10.44) were each associated with indomethacin failure. Conclusion: Age, surfactant use, and CYP2C9*2 influence indomethacin treatment outcome in preterm infants with PDA. This combination of clinical and genetic factors may facilitate targeted indomethacin use for PDA.
Details
- Title: Subtitle
- CYP2C92 is associated with indomethacin treatment failure for patent ductus arteriosus
- Creators
- Sydney R Rooney - Vanderbilt University School of Medicine, UCSF, Nashville, TN 37232, USAElaine L Shelton - Department of Pediatrics, Vanderbilt University Medical Center, UCSF, Nashville, TN 37232, USAIda Aka - Department of Pediatrics, Vanderbilt University Medical Center, UCSF, Nashville, TN 37232, USAChristian M Shaffer - Department of Medicine, Vanderbilt University Medical Center, UCSF, Nashville, TN 37232, USARonald I Clyman - Department of Pediatrics & Cardiovascular Research Center, University of California San Francisco, San Francisco, CA 94143, USAJohn M Dagle - Department of Pediatrics, University of Iowa, Iowa City, UMKC, IA 52242, USAKelli Ryckman - Department of Epidemiology, University of Iowa, Iowa City, UMKC, IA 52242, USATamorah R Lewis - Department of Pediatrics, University of Missouri Kansas City School of Medicine, Kansas City, MO 64110, USAJeff Reese - Department of Pediatrics, Vanderbilt University Medical Center, UCSF, Nashville, TN 37232, USASara L Van Driest - Department of Pediatrics, Vanderbilt University Medical Center, UCSF, Nashville, TN 37232, USA, Department of Medicine, Vanderbilt University Medical Center, UCSF, Nashville, TN 37232, USAPrince J Kannankeril - Department of Pediatrics, Vanderbilt University Medical Center, UCSF, Nashville, TN 37232, USA
- Resource Type
- Journal article
- Publication Details
- Pharmacogenomics, Vol.20(13), pp.939-946
- DOI
- 10.2217/pgs-2019-0079
- PMID
- 31486736
- PMCID
- PMC6817966
- ISSN
- 1462-2416
- eISSN
- 1744-8042
- Language
- English
- Date published
- 08/2019
- Academic Unit
- Stead Family Department of Pediatrics; Epidemiology; Biochemistry and Molecular Biology; Neonatology
- Record Identifier
- 9984214940502771
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