Journal article
Ca²⁺ microdomains organized by junctophilins
Cell calcium (Edinburgh), Vol.58(4), pp.349-356
10/2015
DOI: 10.1016/j.ceca.2015.01.007
PMCID: PMC5159448
PMID: 25659516
Abstract
•Three-dimensional electron microscopy is providing the new knowledge of junctional membrane complexes (JMCs).•Junctophlins (JPs) are essential to structure JMCs in excitable cells.•Quantitative and qualitative alterations of JPs are associated with a wide range of human diseases.
Excitable cells typically possess junctional membrane complexes (JMCs) constructed by the plasma membrane and the endo/sarcoplasmic reticulum (ER/SR) for channel crosstalk. These JMCs are termed triads in skeletal muscle, dyads in cardiac muscle, peripheral couplings in smooth and developing striated muscles, and subsurface cisterns in neurons. Junctophilin subtypes contribute to the formation and maintenance of JMCs by serving as a physical bridge between the plasma membrane and ER/SR membrane in different cell types. In muscle cells, junctophilin deficiency prevents JMC formation and functional crosstalk between cell-surface Ca2+ channels and ER/SR Ca2+ release channels. Human genetic mutations in junctophilin subtypes are linked to congenital hypertrophic cardiomyopathy and neurodegenerative diseases. Furthermore, growing evidence suggests that dysregulation of junctophilins induces pathological alterations in skeletal and cardiac muscle.
Details
- Title: Subtitle
- Ca²⁺ microdomains organized by junctophilins
- Creators
- Hiroshi Takeshima - Kyoto UniversityMasahiko Hoshijima - University of California San DiegoLong-Sheng Song - Roy J. and Lucille A. Carver College of Medicine
- Resource Type
- Journal article
- Publication Details
- Cell calcium (Edinburgh), Vol.58(4), pp.349-356
- DOI
- 10.1016/j.ceca.2015.01.007
- PMID
- 25659516
- PMCID
- PMC5159448
- NLM abbreviation
- Cell Calcium
- ISSN
- 0143-4160
- eISSN
- 1532-1991
- Publisher
- Elsevier Ltd
- Grant note
- name: JSPS Core-to-Core Program; DOI: 10.13039/100004412, name: Human Frontier Science Program, award: RGP0027/2013; name: MEXT Platform for Drug Discovery, Informatics and Structural Life Science; name: US NIH, award: R01 HL090905; DOI: 10.13039/100000968, name: American Heart Association, award: 0635056N, 0840013N; DOI: 10.13039/100007449, name: Takeda Science Foundation
- Language
- English
- Date published
- 10/2015
- Academic Unit
- Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology; Internal Medicine
- Record Identifier
- 9984288728402771
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