Ca2+/cAMP response element-binding protein (CREB)-dependent activation of Per1 is required for light-induced signaling in the suprachiasmatic nucleus circadian clock

Shelley A Tischkau; Jennifer W Mitchell; Sheue-Houy Tyan; Gordon F Buchanan; Martha U Gillette

doi:10.1074/jbc.M209241200

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Ca2+/cAMP response element-binding protein (CREB)-dependent activation of Per1 is required for light-induced signaling in the suprachiasmatic nucleus circadian clock

Journal article

Open access

Peer reviewed

Ca2+/cAMP response element-binding protein (CREB)-dependent activation of Per1 is required for light-induced signaling in the suprachiasmatic nucleus circadian clock

Shelley A Tischkau, Jennifer W Mitchell, Sheue-Houy Tyan, Gordon F Buchanan and Martha U Gillette

The Journal of biological chemistry, Vol.278(2), pp.718-723

01/10/2003

DOI: 10.1074/jbc.M209241200

PMID: 12409294

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Abstract

Light is a prominent stimulus that synchronizes endogenous circadian rhythmicity to environmental light/dark cycles. Nocturnal light elevates mRNA of the Period1 (Per1) gene and induces long term state changes, expressed as phase shifts of circadian rhythms. The cellular mechanism for Per1 elevation and light-induced phase advance in the suprachiasmatic nucleus (SCN), a process initiated primarily by glutamatergic neurotransmission from the retinohypothalamic tract, was examined. Glutamate (GLU)-induced phase advances in the rat SCN were blocked by antisense oligodeoxynucleotide (ODN) against Per1 and Ca(2+)/cAMP response element (CRE)-decoy ODN. CRE-decoy ODN also blocked light-induced phase advances in vivo. Furthermore, the CRE-decoy blocked GLU-induced accumulation of Per1 mRNA. Thus, Ca(2+)/cAMP response element-binding protein (CREB) and Per1 are integral components of the pathway transducing light-stimulated GLU neurotransmission into phase advance of the circadian clock.

Glutamic Acid - pharmacology

Rats, Long-Evans

Gene Expression Regulation

Rats

Male

Nitric Oxide - physiology

Circadian Rhythm - physiology

Cyclic AMP Response Element-Binding Protein - physiology

Period Circadian Proteins

Suprachiasmatic Nucleus - physiology

Cyclic AMP-Dependent Protein Kinases - physiology

Animals

Calcium - physiology

Light

Glutamic Acid - secretion

Mice

Nuclear Proteins - genetics

Response Elements - physiology

Cell Cycle Proteins

Details

Title: Subtitle: Ca2+/cAMP response element-binding protein (CREB)-dependent activation of Per1 is required for light-induced signaling in the suprachiasmatic nucleus circadian clock
Creators: Shelley A Tischkau - Department of Cell and Structural Biology, University of Illinois at Urbana-Champaign, B107 CLSL, 61801, USA
Jennifer W Mitchell
Sheue-Houy Tyan
Gordon F Buchanan
Martha U Gillette
Resource Type: Journal article
Publication Details: The Journal of biological chemistry, Vol.278(2), pp.718-723
DOI: 10.1074/jbc.M209241200
PMID: 12409294
NLM abbreviation: J Biol Chem
ISSN: 0021-9258
eISSN: 1083-351X
Publisher: United States
Grant note: HL67007 / NHLBI NIH HHS R01 NS022155 / NINDS NIH HHS NS22155 / NINDS NIH HHS NS11158 / NINDS NIH HHS R01 HL067007 / NHLBI NIH HHS MH12351 / NIMH NIH HHS NS10170 / NINDS NIH HHS
Language: English
Date published: 01/10/2003
Academic Unit: Neurology; Iowa Neuroscience Institute
Record Identifier: 9984020762802771

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