Journal article
CaMKII, an emerging molecular driver for calcium homeostasis, arrhythmias, and cardiac dysfunction
Journal of molecular medicine (Berlin, Germany), Vol.85(1), pp.5-14
01/2007
DOI: 10.1007/s00109-006-0125-6
PMID: 17119905
Abstract
Maintenance of cytoplasmic calcium homeostasis is critical for all cells. An exciting field has emerged in elucidating the multiple roles that Ca2+/calmodulin-dependent protein kinase II (CaMKII) plays in regulating Ca2+ cycling in normal cardiac myocytes and in pathophysiological states. Moreover, CaMKII was recently identified as a potential drug target in cardiac disease. This work has given us a closer view of the complexity and therapeutic possibilities of CaMKII regulation of Ca2+ signaling in cardiac myocytes.
Details
- Title: Subtitle
- CaMKII, an emerging molecular driver for calcium homeostasis, arrhythmias, and cardiac dysfunction
- Creators
- Chad Grueter - Department of Molecular Physiology and Biophysics Vanderbilt University Medical Center Nashville TN USARoger Colbran - The Vanderbilt-Kennedy Center for Research on Human Development Vanderbilt University Medical Center Nashville TN USAMark Anderson - Department of Internal Medicine, Carver College of Medicine University of Iowa 200 Hawkins Drive, RM E315 GH Iowa IA 52242-1081 USA
- Resource Type
- Journal article
- Publication Details
- Journal of molecular medicine (Berlin, Germany), Vol.85(1), pp.5-14
- DOI
- 10.1007/s00109-006-0125-6
- PMID
- 17119905
- NLM abbreviation
- J Mol Med (Berl)
- ISSN
- 0946-2716
- eISSN
- 1432-1440
- Publisher
- Springer-Verlag
- Language
- English
- Date published
- 01/2007
- Academic Unit
- Cardiovascular Medicine; Craniofacial Anomalies Research Center; Internal Medicine
- Record Identifier
- 9984094599802771
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