Journal article
Caffeine delays autonomic recovery following acute exercise
European journal of preventive cardiology, Vol.22(11), pp.1473-1479
11/01/2015
DOI: 10.1177/2047487314554867
PMID: 25297344
Abstract
Background: Impaired autonomic recovery of heart rate ( HR) following exercise is associated with an increased risk of sudden death. Caffeine, a potent stimulator of catecholamine release, has been shown to augment blood pressure ( BP) and sympathetic nerve activity; however, whether caffeine alters autonomic function after a bout of exercise bout remains unclear. Methods: In a randomized, crossover study, 18 healthy individuals ( 26 +/- 1 years; 23.9 +/- 0.8 kg . m +/- 2) ingested caffeine ( 400 mg) or placebo pills, followed by a maximal treadmill test to exhaustion. Autonomic function and ventricular depolarization/ repolarization were determined using heart rate variability ( HRV) and corrected QT interval ( QTc), respectively, at baseline, 5, 15, and 30 minutes post- exercise. Results: Maximal HR ( HRmax) was greater with caffeine ( 192 +/- 2 vs. 190 +/- 2 beat . min - 1, p< 0.05). During recovery, HR, mean arterial pressure ( MAP), and diastolic blood pressure ( DBP) remained elevated with caffeine ( p< 0.05). Natural log transformation of low-to-high frequency ratio ( LnLF/LnHF) of HRV was increased compared with baseline at all time points in both trials ( p< 0.05), with less of an increase during 5 and 15 minutes post- exercise in the caffeine trial ( p< 0.05). QTc increased from baseline at all time points in both trials, with greater increases in the caffeine trial ( p< 0.05). Conclusions: Caffeine ingestion disrupts post- exercise autonomic recovery because of increased sympathetic nerve activity. The prolonged sympathetic recovery time could subsequently hinder baroreflex function during recovery and disrupt the stability of autonomic function, potentiating a pro-arrhythmogenic state in young adults.
Details
- Title: Subtitle
- Caffeine delays autonomic recovery following acute exercise
- Creators
- Kanokwan Bunsawat - University of Illinois ChicagoDaniel W. White - University of Illinois ChicagoRebecca M. Kappus - University of Illinois Urbana-ChampaignTracy Baynard - University of Illinois Urbana-Champaign
- Resource Type
- Journal article
- Publication Details
- European journal of preventive cardiology, Vol.22(11), pp.1473-1479
- DOI
- 10.1177/2047487314554867
- PMID
- 25297344
- NLM abbreviation
- Eur J Prev Cardiol
- ISSN
- 2047-4873
- eISSN
- 2047-4881
- Publisher
- Oxford Univ Press
- Number of pages
- 7
- Language
- English
- Date published
- 11/01/2015
- Academic Unit
- Health, Sport, and Human Physiology
- Record Identifier
- 9984948140902771
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