Journal article
Calcification of Glutaraldehyde Cross-Linked Collagen in Bladder Neck Injections in Children With Incontinence: A Long-Term Complication
The Journal of urology, Vol.176(3), pp.1143-1146
09/2006
DOI: 10.1016/j.juro.2006.04.059
PMID: 16890711
Abstract
Purpose:
We report the incidence of calcifications developing at the bladder neck/urethra in pediatric patients treated with glutaraldehyde cross-linked collagen for urinary incontinence.
Materials and Methods:
We reviewed charts of patients treated with glutaraldehyde cross-linked collagen injections for urinary incontinence between 1994 and 1999. Etiology of incontinence, pertinent medical history, operative details and postoperative imaging were examined.
Results:
Of 31 patients 4 (13%) had development of submucosal calcifications in the bladder neck/urethra. All 4 patients had received multiple injections of glutaraldehyde cross-linked collagen for incontinence secondary to neurogenic bladder. The calcifications were confirmed surgically. Pathology reports available for 2 of 4 patients showed chronic inflammation without dysplasia or malignant changes. Mean followup was significantly different between calcified and noncalcified cases (10.3 vs 7.2 years, p = 0.009), as was total volume of collagen injected (21 vs 12 cc, p = 0.012). Mean time to diagnosis of calcifications was 8.8 years (range 7 to 11) after first injection. A total of 24 patients without calcification underwent bladder imaging at a mean of 6.8 years (±2.2) after glutaraldehyde cross-linked collagen injection, which was not significantly different than the time to diagnosis (p = 0.089). The number of injections was not significantly different between the 2 groups (p = 0.426).
Conclusions:
Of our patients 13% had development of calcifications at the site of prior glutaraldehyde cross-linked collagen injections for incontinence. These calcifications were surrounded by chronic inflammation. Patients who have undergone glutaraldehyde cross-linked collagen injections may benefit from long-term followup with bladder imaging to detect and follow calcifications at prior injection sites.
Details
- Title: Subtitle
- Calcification of Glutaraldehyde Cross-Linked Collagen in Bladder Neck Injections in Children With Incontinence: A Long-Term Complication
- Creators
- Matthew J Knudson - Division of Pediatric Urology, Department of Urology, University of Iowa, Iowa City, IowaChristopher S Cooper - Division of Pediatric Urology, Department of Urology, University of Iowa, Iowa City, IowaCraig A Block - Division of Pediatric Urology, Department of Urology, University of Iowa, Iowa City, IowaCharles E Hawtrey - Division of Pediatric Urology, Department of Urology, University of Iowa, Iowa City, IowaJ. Christopher Austin - Division of Pediatric Urology, Department of Urology, University of Iowa, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- The Journal of urology, Vol.176(3), pp.1143-1146
- DOI
- 10.1016/j.juro.2006.04.059
- PMID
- 16890711
- ISSN
- 0022-5347
- eISSN
- 1527-3792
- Language
- English
- Date published
- 09/2006
- Academic Unit
- Stead Family Department of Pediatrics; Urology; Medicine Administration
- Record Identifier
- 9984051559502771
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