Calcifying pseudoneoplasm of the neuraxis (CAPNON): an institutional series of ten cases and review of the literature to date

Cecile Riviere-Cazaux; Lucas P. Carlstrom; Kathryn L. Eschbacher; Aditya Raghunathan; Christopher S. Graffeo; Fredric B. Meyer

doi:10.1016/j.wneu.2023.10.004

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Calcifying pseudoneoplasm of the neuraxis (CAPNON): an institutional series of ten cases and review of the literature to date

Journal article

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Calcifying pseudoneoplasm of the neuraxis (CAPNON): an institutional series of ten cases and review of the literature to date

Cecile Riviere-Cazaux, Lucas P. Carlstrom, Kathryn L. Eschbacher, Aditya Raghunathan, Christopher S. Graffeo and Fredric B. Meyer

World neurosurgery, Vol.180, pp.e653-e666

12/2023

DOI: 10.1016/j.wneu.2023.10.004

PMCID: PMC11801208

PMID: 37813339

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https://pmc.ncbi.nlm.nih.gov/articles/PMC11801208/pdf/nihms-2044907.pdfView

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Abstract

Calcified pseudoneoplasm of the neuraxis (CAPNONs) are rare, fibro-osseous lesions with an unknown etiology that may present anywhere along the neuroaxis. Little is known about how intracranial CAPNONs present and patients’ long-term outcomes. A retrospective institutional review of intracranial pathology-confirmed CAPNONs was performed. Presenting clinical features, management, and clinical outcomes are highlighted. A literature review on intracranial CAPNON lesions was also performed to build upon our series. Ten patients were identified that met inclusion criteria. Most patients presented with headaches (n=6, 60%), seizures (n=5, 50.0%), and neck and facial pain (n=3, 30.0%). Most lesions were supratentorial, (n=7, 70.0%), with three infratentorial origins. Surgical resection was the most common initial management undertaken (n=7, 70.0 %). No new permanent post-operative neurological deficits were identified. The median clinical and/or radiographic follow-up for all patients was 6.8 years (range 0.7-23.3 years), with no recurrence of disease for five patients that underwent gross total resection. Four of five patients with residual or non-resectable lesions showed no interval growth on radiographic follow up; one patient demonstrated progression and worsening of presenting symptoms two months after resection. Resection substantially improved seizures and headaches in patients presenting with these symptoms (80% and 83.3%, respectively). Intracranial CAPNONs may present with a wide variety of symptoms characteristic of the site of origin. The outcomes of these regarding survival and disease control are generally favorable, although resection does not always yield complete resolution of presenting deficits in certain patients, particularly those presenting with headaches or neck/facial pain.

calcified pseudoneoplasm

calcifying pseudoneoplasm

CAPNON

CRUDoma

fibro-osseous

Details

Title: Subtitle: Calcifying pseudoneoplasm of the neuraxis (CAPNON): an institutional series of ten cases and review of the literature to date
Creators: Cecile Riviere-Cazaux - Mayo Clinic
Lucas P. Carlstrom - Mayo Clinic
Kathryn L. Eschbacher - University of Iowa
Aditya Raghunathan - Mayo Clinic
Christopher S. Graffeo - University of Oklahoma
Fredric B. Meyer - Mayo Clinic
Resource Type: Journal article
Publication Details: World neurosurgery, Vol.180, pp.e653-e666
DOI: 10.1016/j.wneu.2023.10.004
PMID: 37813339
PMCID: PMC11801208
NLM abbreviation: World Neurosurg
ISSN: 1878-8750
eISSN: 1878-8769
Publisher: Elsevier Inc
Grant note: DOI: 10.13039/100007048, name: Mayo Clinic
Language: English
Electronic publication date: 10/07/2023
Date published: 12/2023
Academic Unit: Pathology
Record Identifier: 9984476545902771

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