Journal article
Calcitonin gene-related peptide: an update on the biology
Current opinion in neurology, Vol.22(3), pp.241-246
06/2009
DOI: 10.1097/WCO.0b013e32832b2427
PMCID: PMC2844706
PMID: 19434786
Abstract
Purpose of review
This review includes the most relevant and recent studies on the biology of calcitonin gene-related peptide (CGRP) as it pertains to primary headaches and particularly to migraine. Especial attention was given to those published within the last year.
Recent findings
The development of CGRP receptor antagonists is discussed in detail, as well as recent advances in our understanding of CGRP actions in migraine. Finally, other important functions of CGRP outside of the nervous system are briefly discussed.
Summary
The advent of CGRP receptor antagonists as a novel therapy for migraine attacks may represent a new era in the acute management of migraine. More than a simple addition to the currently available treatments, this group of drugs may become an outstanding option for patients with cardiovascular disease, given the lack of associated vasoconstriction. Furthermore, nonpeptide CGRP receptor antagonists, CGRP antibodies and CGRP-binding RNA-Spiegelmer are valuable research tools that will further advance our understanding of migraine pathophysiology.
Details
- Title: Subtitle
- Calcitonin gene-related peptide: an update on the biology
- Creators
- Ana Recober - Department of Neurology, University of Iowa, Iowa City, Iowa, USAAndrew F Russo - Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- Current opinion in neurology, Vol.22(3), pp.241-246
- DOI
- 10.1097/WCO.0b013e32832b2427
- PMID
- 19434786
- PMCID
- PMC2844706
- NLM abbreviation
- Curr Opin Neurol
- ISSN
- 1350-7540
- eISSN
- 1473-6551
- Language
- English
- Date published
- 06/2009
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute; Craniofacial Anomalies Research Center
- Record Identifier
- 9984020882802771
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