Calcitonin gene-related peptide in migraine: intersection of peripheral inflammation and central modulation

Ann C Raddant; Andrew F Russo

doi:10.1017/S1462399411002067

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Calcitonin gene-related peptide in migraine: intersection of peripheral inflammation and central modulation

Journal article

Peer reviewed

Calcitonin gene-related peptide in migraine: intersection of peripheral inflammation and central modulation

Ann C Raddant and Andrew F Russo

Expert reviews in molecular medicine, Vol.13, pp.e36-e36

11/29/2011

DOI: 10.1017/S1462399411002067

PMCID: PMC3383830

PMID: 22123247

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https://www.ncbi.nlm.nih.gov/pmc/articles/3383830View

Open Access

Abstract

Over the past two decades, a convergence of basic and clinical evidence has established the neuropeptide calcitonin-gene-related peptide (CGRP) as a key player in migraine. Although CGRP is a recognised neuromodulator of nociception, its mechanism of action in migraine remains elusive. In this review, we present evidence that led us to propose that CGRP is well poised to enhance neurotransmission in migraine by both peripheral and central mechanisms. In the periphery, it is thought that local release of CGRP from the nerve endings of meningeal nociceptors following their initial activation by cortical spreading depression is critical for the induction of vasodilation, plasma protein extravasation, neurogenic inflammation and the consequential sensitisation of meningeal nociceptors. Mechanistically, we propose that CGRP release can give rise to a positive-feedback loop involved in localised increased synthesis and release of CGRP from neurons and a CGRP-like peptide called procalcitonin from trigeminal ganglion glia. Within the brain, the wide distribution of CGRP and CGRP receptors provides numerous possible targets for CGRP to act as a neuromodulator.

Animals

Hypothalamus - metabolism

Migraine Disorders - genetics

Humans

Neurogenic Inflammation - genetics

Calcitonin Gene-Related Peptide - genetics

Neurogenic Inflammation - metabolism

Neuroglia - metabolism

Nociceptors - metabolism

Calcitonin Gene-Related Peptide - metabolism

Migraine Disorders - metabolism

Details

Title: Subtitle: Calcitonin gene-related peptide in migraine: intersection of peripheral inflammation and central modulation
Creators: Ann C Raddant - Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA
Andrew F Russo
Resource Type: Journal article
Publication Details: Expert reviews in molecular medicine, Vol.13, pp.e36-e36
DOI: 10.1017/S1462399411002067
PMID: 22123247
PMCID: PMC3383830
NLM abbreviation: Expert Rev Mol Med
ISSN: 1462-3994
eISSN: 1462-3994
Publisher: England
Grant note: NS075599 / NINDS NIH HHS R01 NS075599 / NINDS NIH HHS F31 NS074728 / NINDS NIH HHS R01 DE016511 / NIDCR NIH HHS NS074728 / NINDS NIH HHS DE016511 / NIDCR NIH HHS
Language: English
Date published: 11/29/2011
Academic Unit: Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute; Craniofacial Anomalies Research Center
Record Identifier: 9984020651402771

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