Journal article
Calcium: Amplitude, Duration, or Location?
The Biological bulletin (Lancaster), Vol.228(1), pp.75-83
02/01/2015
DOI: 10.1086/BBLv228n1p75
PMCID: PMC4436677
PMID: 25745102
Abstract
Calcium plays a role in long term plasticity by triggering post-synaptic signaling pathways for both the strengthening (LTP) and weakening (LTD) of synapses. Since these are opposing processes, several hypotheses have been developed to explain how calcium can trigger LTP in some situations and LTD in others. These hypotheses fall broadly into three categories, based on the amplitude of calcium concentration, the duration of the calcium elevation, and the location of the calcium influx. Here we review the experimental evidence for and against each of these hypotheses and the recent computational models utilizing each. We argue that with new experimental techniques for the precise visualization of calcium and new computational techniques for the modeling of calcium diffusion, it is time to take a new look at the location hypothesis.
Details
- Title: Subtitle
- Calcium: Amplitude, Duration, or Location?
- Creators
- Rc EvansKt Blackwell
- Resource Type
- Journal article
- Publication Details
- The Biological bulletin (Lancaster), Vol.228(1), pp.75-83
- DOI
- 10.1086/BBLv228n1p75
- PMID
- 25745102
- PMCID
- PMC4436677
- NLM abbreviation
- Biol Bull
- ISSN
- 0006-3185
- eISSN
- 1939-8697
- Language
- English
- Date published
- 02/01/2015
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Iowa Neuroscience Institute
- Record Identifier
- 9984446516502771
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