Journal article
Calcium and the effects of ultrasound on frog skin
Ultrasound in medicine & biology, Vol.20(1), pp.73-81
1994
DOI: 10.1016/0301-5629(94)90019-1
PMID: 8197629
Abstract
Therapeutic ultrasound is used to enhance the repair of soft tissue, muscle, etc., and because many of the cellular reactions involved in these processes are dependent on the intracellular availability of free calcium ions, it becomes important to study the effects of ultrasound in the presence and the absence of calcium ions. Using frog skin as a biological model, the effect of therapeutic ultrasound (300 mW/cm
2 1 MHz CW) was investigated. Sonication for two minutes caused a significantly larger increase in total ionic conductance (
G
t
) in the presence of calcium ions (140% vs. 27%). However, the time constant for
G
t
to return to steady state was significantly longer in calcium-free solutions (122 vs. 18 min.). This study demonstrates that the biological effects of ultrasound are influenced by calcium ions. Furthermore, the recovery time constants confirm recent findings regarding the function of calcium ions in the formation of tight junctions. The role of free radicals produced by cavitation and calcium potentiated lipid and protein peroxidation is discussed.
Details
- Title: Subtitle
- Calcium and the effects of ultrasound on frog skin
- Creators
- Anan M Al-Karmi - Department of Physics and Astronomy, Biophysics Laboratory, The University of Mississippi, University, MS, USAMumtaz A Dinno - Department of Physics, East Carolina University, Greenville, NC, USADavid A Stoltz - Department of Physics and Astronomy, Biophysics Laboratory, The University of Mississippi, University, MS, USALawrence A Crum - Applied Physics Laboratory, University of Washington, Seattle, WA, USAJohn C Matthews - Department of Pharmacology and Research Institute of Pharmaceutical Sciences, The University of Mississippi, University, MS, USA
- Resource Type
- Journal article
- Publication Details
- Ultrasound in medicine & biology, Vol.20(1), pp.73-81
- Publisher
- Elsevier Inc
- DOI
- 10.1016/0301-5629(94)90019-1
- PMID
- 8197629
- ISSN
- 0301-5629
- eISSN
- 1879-291X
- Language
- English
- Date published
- 1994
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
- Record Identifier
- 9984025405902771
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