Calcium-dependent inactivation of calcium channels in the medial striatum increases at eye opening

R C Evans; G A Herin; S L Hawes; K T Blackwell

doi:10.1152/jn.00818.2014

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Calcium-dependent inactivation of calcium channels in the medial striatum increases at eye opening

Journal article

Open access

Peer reviewed

Calcium-dependent inactivation of calcium channels in the medial striatum increases at eye opening

R C Evans, G A Herin, S L Hawes and K T Blackwell

Journal of neurophysiology, Vol.113(7), pp.2979-2986

04/01/2015

DOI: 10.1152/jn.00818.2014

PMCID: PMC4416611

PMID: 25673739

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https://europepmc.org/articles/pmc4416611View

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Abstract

Influx of calcium through voltage-gated calcium channels (VGCCs) is essential for striatal function and plasticity. VGCCs expressed in striatal neurons have varying kinetics, voltage dependences, and densities resulting in heterogeneous subcellular calcium dynamics. One factor that determines the calcium dynamics in striatal medium spiny neurons is inactivation of VGCCs. Aside from voltage-dependent inactivation, VGCCs undergo calcium-dependent inactivation (CDI): inactivating in response to an influx of calcium. CDI is a negative feedback control mechanism; however, its contribution to striatal neuron function is unknown. Furthermore, although the density of VGCC expression changes with development, it is unclear whether CDI changes with development. Because calcium influx through L-type calcium channels is required for striatal synaptic depression, a change in CDI could contribute to age-dependent changes in striatal synaptic plasticity. Here we use whole cell voltage clamp to characterize CDI over developmental stages and across striatal regions. We find that CDI increases at the age of eye opening in the medial striatum but not the lateral striatum. The developmental increase in CDI mostly involves L-type channels, although calcium influx through non-L-type channels contributes to the CDI in both age groups. Agents that enhance protein kinase A (PKA) phosphorylation of calcium channels reduce the magnitude of CDI after eye opening, suggesting that the developmental increase in CDI may be related to a reduction in the phosphorylation state of the L-type calcium channel. These results are the first to show that modifications in striatal neuron properties correlate with changes to sensory input.

Aging - physiology

Animals

Calcium - metabolism

Calcium Channels, L-Type - physiology

Calcium Signaling - physiology

Corpus Striatum - physiology

Eye Movements - physiology

Female

Ion Channel Gating - physiology

Male

Mice

Mice, Inbred C57BL

Neuronal Plasticity - physiology

Wakefulness - physiology

Details

Title: Subtitle: Calcium-dependent inactivation of calcium channels in the medial striatum increases at eye opening
Creators: R C Evans - George Mason University
G A Herin - Eastern Mennonite University
S L Hawes - George Mason University
K T Blackwell - George Mason University
Resource Type: Journal article
Publication Details: Journal of neurophysiology, Vol.113(7), pp.2979-2986
DOI: 10.1152/jn.00818.2014
PMID: 25673739
PMCID: PMC4416611
NLM abbreviation: J Neurophysiol
ISSN: 0022-3077
eISSN: 1522-1598
Grant note: R01 AA016022 / NIAAA NIH HHS R01 DA038890 / NIDA NIH HHS R01-DA-038890 / NIDA NIH HHS 1F31-NS-066645 / NINDS NIH HHS
Language: English
Date published: 04/01/2015
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Iowa Neuroscience Institute
Record Identifier: 9984446428402771

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