Journal article
Calcium dynamics integrated into signalling pathways that influence vertebrate axial patterning
Philosophical transactions. Biological sciences, Vol.363(1495), pp.1377-1385
04/12/2008
DOI: 10.1098/rstb.2007.2255
PMCID: PMC2610126
PMID: 18198152
Abstract
Many aspects of animal development including fertilization as well as organ formation and function are dependent upon the dynamic release of calcium (Ca(2+)) ions. Although the controlled release and/or accumulation of Ca(2+) ions has been extensively studied, how the release dynamics produce a specific biological output in embryonic development is less clear. We will briefly summarize Ca(2+) sources, highlight data on endogenous Ca(2+) release in vertebrate embryos relevant to body plan formation and cell movement, and integrate pharmacological and molecular-genetic studies to lend insight into the signalling pathways involved. Finally, based on in vivo imaging in zebrafish genetic mutants, we will put forward the model that distinct Ca(2+) release dynamics lead to antagonism of the developmentally important Wnt/beta-catenin signalling pathway, while sustained Ca(2+) release modulates cell polarization or directed migration.
Details
- Title: Subtitle
- Calcium dynamics integrated into signalling pathways that influence vertebrate axial patterning
- Creators
- Christina M Freisinger - Department of Biology, University of Iowa, Iowa City, IA 52242, USAIgor SchneiderTrudi A WestfallDiane C Slusarski
- Resource Type
- Journal article
- Publication Details
- Philosophical transactions. Biological sciences, Vol.363(1495), pp.1377-1385
- DOI
- 10.1098/rstb.2007.2255
- PMID
- 18198152
- PMCID
- PMC2610126
- NLM abbreviation
- Philos Trans R Soc Lond B Biol Sci
- ISSN
- 0962-8436
- eISSN
- 1471-2970
- Publisher
- England
- Language
- English
- Date published
- 04/12/2008
- Academic Unit
- Iowa Neuroscience Institute; Biology
- Record Identifier
- 9983991959102771
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