Calcium effect on generation and amplification of myokymic discharges

J F Brick; L Gutmann; C F McComas

doi:10.1212/WNL.32.6.618

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Calcium effect on generation and amplification of myokymic discharges

Journal article

Peer reviewed

Calcium effect on generation and amplification of myokymic discharges

J F Brick, L Gutmann and C F McComas

Neurology, Vol.32(6), pp.618-622

06/1982

DOI: 10.1212/WNL.32.6.618

PMID: 6283421

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Abstract

Maneuvers designed to manipulate ionized calcium (Ca++) were carried out in two patients with inflammatory polyradiculoneuropathy and myokymia. Increased clinical myokymia and myokymic burst amplification occurred when ionized Ca++ was lowered by plasma exchange or hyperventilation. Increasing ionized Ca++ (by intravenous infusion of CaCl2) decreased the myokymia. These findings indicate that myokymic discharges are altered by changes in serum ionized Ca++ and effects on axonal excitability.

Calcium - metabolism

Humans

Hyperventilation - complications

Ulnar Nerve - physiopathology

Peripheral Nervous System Diseases - physiopathology

Plasma Exchange

Myoclonus - physiopathology

Peripheral Nervous System Diseases - metabolism

Peroneal Nerve - physiopathology

Myoclonus - metabolism

Myoclonus - complications

Median Nerve - physiopathology

Adult

Female

Aged

Electromyography

Peripheral Nervous System Diseases - complications

Details

Title: Subtitle: Calcium effect on generation and amplification of myokymic discharges
Creators: J F Brick
L Gutmann
C F McComas
Resource Type: Journal article
Publication Details: Neurology, Vol.32(6), pp.618-622
Publisher: United States
DOI: 10.1212/WNL.32.6.618
PMID: 6283421
ISSN: 0028-3878
eISSN: 1526-632X
Language: English
Date published: 06/1982
Academic Unit: Neurology
Record Identifier: 9984013109102771

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