Journal article
Calcium in lipid peroxidation: Does calcium interact with superoxide?
Archives of biochemistry and biophysics, Vol.278(1), pp.269-272
1990
DOI: 10.1016/0003-9861(90)90258-Z
PMID: 2157359
Abstract
Using a pulse radiolysis approach to generate and observe superoxide anions (O
−
2
̇
) in the absence and presence of calcium, we have attempted to verify the recent hypothesis of Babizhayev (
Arch. Biochem. Biophys. 266, 446–451, 1988) of a Ca
2+O
−
2
̇
interaction during lipid peroxidation. We could not observe rapid scavenging of O
−
2
̇
or complex formation with Ca
2+ to account for an inhibitory effect of this cation on lipid peroxidation. Neither could we agree that the stimulatory effect is due to liberation of catalytic ferrous iron from weak complexes by Ca
2+. Drawing on reports in the literature, we propose an alternate explanation for the apparent stimulation of lipid peroxidation by low Ca
2+ concentrations. In our view, this is
not a direct effect, but reflects independently initiated processes of lipid peroxidation and Ca
2+ translocation, which interact
subsequently in a
synergistic manner. The reported inhibition at high Ca
2+ concentrations is considered an artifact as it was observed at levels far in excess of those relevant to animal systems (but not necessarily in some plant compartments).
Details
- Title: Subtitle
- Calcium in lipid peroxidation: Does calcium interact with superoxide?
- Creators
- Wolf Bors - Institute für Strahlenbiologie, GSF Research Center, D-8042 Neuherberg, FRGGarry R Buettner - ESR Center, EMRB 68, University of Iowa, Iowa City, Iowa 52242 U.S.AChrista Michel - Institute für Strahlenbiologie, GSF Research Center, D-8042 Neuherberg, FRGManfred Saran - Institute für Strahlenbiologie, GSF Research Center, D-8042 Neuherberg, FRG
- Resource Type
- Journal article
- Publication Details
- Archives of biochemistry and biophysics, Vol.278(1), pp.269-272
- Publisher
- Elsevier Inc
- DOI
- 10.1016/0003-9861(90)90258-Z
- PMID
- 2157359
- ISSN
- 0003-9861
- eISSN
- 1096-0384
- Language
- English
- Date published
- 1990
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984046809002771
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