Journal article
Calcium signaling in vertebrate embryonic patterning and morphogenesis
Developmental biology, Vol.307(1), pp.1-13
07/01/2007
DOI: 10.1016/j.ydbio.2007.04.043
PMCID: PMC2729314
PMID: 17531967
Abstract
Signaling pathways that rely on the controlled release and/or accumulation of calcium ions are important in a variety of developmental events in the vertebrate embryo, affecting cell fate specification and morphogenesis. One such major developmentally important pathway is the Wnt/calcium signaling pathway, which, through its antagonism of Wnt/beta-catenin signaling, appears to regulate the formation of the early embryonic organizer. In addition, the Wnt/calcium pathway shares components with another non-canonical Wnt pathway involved in planar cell polarity, suggesting that these two pathways form a loose network involved in polarized cell migratory movements that fashion the vertebrate body plan. Furthermore, left-right axis determination, neural induction and somite formation also display dynamic calcium release, which may be critical in these patterning events. Finally, we summarize recent evidence that propose a role for calcium signaling in stem cell biology and human developmental disorders.
Details
- Title: Subtitle
- Calcium signaling in vertebrate embryonic patterning and morphogenesis
- Creators
- Diane C Slusarski - Department of Biological Sciences, University of Iowa, Iowa City, IA 52242, USAFrancisco Pelegri
- Resource Type
- Journal article
- Publication Details
- Developmental biology, Vol.307(1), pp.1-13
- DOI
- 10.1016/j.ydbio.2007.04.043
- PMID
- 17531967
- PMCID
- PMC2729314
- NLM abbreviation
- Dev Biol
- ISSN
- 0012-1606
- eISSN
- 1095-564X
- Publisher
- United States
- Grant note
- R01 GM065303-05 / NIGMS NIH HHS R01 GM065303 / NIGMS NIH HHS
- Language
- English
- Date published
- 07/01/2007
- Academic Unit
- Iowa Neuroscience Institute; Biology
- Record Identifier
- 9983991961102771
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