Calcium/calmodulin-dependent protein kinase II and potassium channel subunit eag similarly affect plasticity in Drosophila

Leslie C Griffith; Jing Wang; Yi Zhong; Chun-Fang Wu; Ralph J Greenspan

doi:10.1073/pnas.91.21.10044

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Calcium/calmodulin-dependent protein kinase II and potassium channel subunit eag similarly affect plasticity in Drosophila

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Calcium/calmodulin-dependent protein kinase II and potassium channel subunit eag similarly affect plasticity in Drosophila

Leslie C Griffith, Jing Wang, Yi Zhong, Chun-Fang Wu and Ralph J Greenspan

Proceedings of the National Academy of Sciences - PNAS, Vol.91(21), pp.10044-10048

10/11/1994

DOI: 10.1073/pnas.91.21.10044

PMCID: PMC44954

PMID: 7937834

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Abstract

Similar defects in both synaptic transmission and associative learning are produced in Drosophila melanogaster by inhibition of calcium/calmodulin-dependent protein kinase II and mutations in the potassium channel subunit gene eag. These behavioral and synaptic defects are not simply additive in animals carrying both an eag mutation and a transgene for a protein kinase inhibitor, raising the possibility that the phenotypes share a common pathway. At the molecular level, a portion of the putative cytoplasmic domain of Eag is a substrate of calcium/calmodulin-dependent protein kinase II. These similarities in behavior and synaptic physiology, the genetic interaction, and the in vitro biochemical interaction of the two molecules suggest that an important component of neural and behavioral plasticity may be mediated by modulation of Eag function by calcium/calmodulin-dependent protein kinase II.

Details

Title: Subtitle: Calcium/calmodulin-dependent protein kinase II and potassium channel subunit eag similarly affect plasticity in Drosophila
Creators: Leslie C Griffith - Department of Biology, Brandeis University, Waltham, MA 02254
Jing Wang - Brandeis University
Yi Zhong - Brandeis University
Chun-Fang Wu - University of Iowa
Ralph J Greenspan - New York University
Resource Type: Journal article
Publication Details: Proceedings of the National Academy of Sciences - PNAS, Vol.91(21), pp.10044-10048
DOI: 10.1073/pnas.91.21.10044
PMID: 7937834
PMCID: PMC44954
NLM abbreviation: Proc Natl Acad Sci U S A
ISSN: 0027-8424
eISSN: 1091-6490
Publisher: National Academy of Sciences
Language: English
Date published: 10/11/1994
Academic Unit: Iowa Neuroscience Institute; Biology
Record Identifier: 9984070463802771

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