Calcium/vitamin D supplementation, serum 25-hydroxyvitamin D concentrations, and cholesterol profiles in the Women's Health Initiative calcium/vitamin D randomized trial

Peter F Schnatz; Xuezhi Jiang; Sharon Vila-Wright; Aaron K Aragaki; Matthew Nudy; David M O'Sullivan; Rebecca Jackson; Erin LeBlanc; Jennifer G Robinson; James M Shikany; Catherine R Womack; Lisa W Martin; Marian L Neuhouser; Mara Z Vitolins; Yiqing Song; Stephen Kritchevsky; JoAnn E Manson

doi:10.1097/GME.0000000000000188

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Calcium/vitamin D supplementation, serum 25-hydroxyvitamin D concentrations, and cholesterol profiles in the Women's Health Initiative calcium/vitamin D randomized trial

Journal article

Peer reviewed

Calcium/vitamin D supplementation, serum 25-hydroxyvitamin D concentrations, and cholesterol profiles in the Women's Health Initiative calcium/vitamin D randomized trial

Peter F Schnatz, Xuezhi Jiang, Sharon Vila-Wright, Aaron K Aragaki, Matthew Nudy, David M O'Sullivan, Rebecca Jackson, Erin LeBlanc, Jennifer G Robinson, James M Shikany, …

Menopause (New York, N.Y.), Vol.21(8), pp.823-833

08/2014

DOI: 10.1097/GME.0000000000000188

PMCID: PMC5234488

PMID: 24594863

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https://www.ncbi.nlm.nih.gov/pmc/articles/5234488View

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Abstract

The objective of this study was to evaluate whether increased serum 25-hydroxyvitamin D3 (25OHD3) concentrations, in response to calcium/vitamin D (CaD) supplementation, are associated with improved lipids in postmenopausal women. The parent trial was a double-blind, randomized, placebo-controlled, parallel-group trial designed to test the effects of CaD supplementation (1,000 mg of elemental calcium + 400 IU of vitamin D3 daily) versus placebo in postmenopausal women. Women from the general community, including multiple sites in the United States, were enrolled between 1993 and 1998. This cohort included 300 white, 200 African-American, and 100 Hispanic participants who were randomly selected from the Women's Health Initiative CaD trial. Serum 25OHD3 and lipid (fasting plasma triglycerides [TG], high-density lipoprotein cholesterol [HDL-C], and calculated low-density lipoprotein cholesterol [LDL-C]) levels were assessed before and after CaD randomization. There was a 38% increase in mean serum 25OHD3 concentrations after 2 years (95% CI, 1.29-1.47, P < 0.001) for women randomized to CaD (24.3 ng/mL postrandomization mean) compared with placebo (18.2 ng/mL). Women randomized to CaD had a 4.46-mg/dL mean decrease in LDL-C (P = 0.03). Higher concentrations of 25OHD3 were associated with higher HDL-C levels (P = 0.003), along with lower LDL-C and TG levels (P = 0.02 and P < 0.001, respectively). Supplemental CaD significantly increases 25OHD3 concentrations and decreases LDL-C. Women with higher 25OHD3 concentrations have more favorable lipid profiles, including increased HDL-C, lower LDL-C, and lower TG. These results support the hypothesis that higher concentrations of 25OHD3, in response to CaD supplementation, are associated with improved LDL-C.

Hyperlipidemias - blood

Women's Health

Calcifediol - blood

Double-Blind Method

Cholesterol - blood

Humans

Hyperlipidemias - drug therapy

Middle Aged

Treatment Outcome

Calcium, Dietary - administration & dosage

Cholesterol, HDL - blood

Postmenopause

Cholesterol, LDL - blood

Female

Vitamin D - administration & dosage

Dietary Supplements

Details

Title: Subtitle: Calcium/vitamin D supplementation, serum 25-hydroxyvitamin D concentrations, and cholesterol profiles in the Women's Health Initiative calcium/vitamin D randomized trial
Creators: Peter F Schnatz - From the Departments of 1ObGyn and 2Internal Medicine, The Reading Hospital, Reading, PA; Departments of 3ObGyn and 4Internal Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA; 5Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA; 6Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, The Ohio State University, Columbus, OH; 7Center for Health Research NW, Kaiser Permanente, Portland, OR; 8Departments of Epidemiology and Medicine, University of Iowa, Iowa City, IA; 9Division of Preventive Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL; 10Department of Preventive Medicine, University of Tennessee, Memphis, TN; 11Division of Cardiology, Department of Internal Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC; 12Department of Epidemiology and Prevention, Wake Forest University, Winston-Salem, NC; 13Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA; and 14Sticht Center on Aging, Wake Forest University, Winston-Salem, NC
Xuezhi Jiang
Sharon Vila-Wright
Aaron K Aragaki
Matthew Nudy
David M O'Sullivan
Rebecca Jackson
Erin LeBlanc
Jennifer G Robinson
James M Shikany
Catherine R Womack
Lisa W Martin
Marian L Neuhouser
Mara Z Vitolins
Yiqing Song
Stephen Kritchevsky
JoAnn E Manson
Resource Type: Journal article
Publication Details: Menopause (New York, N.Y.), Vol.21(8), pp.823-833
DOI: 10.1097/GME.0000000000000188
PMID: 24594863
PMCID: PMC5234488
NLM abbreviation: Menopause
ISSN: 1530-0374
eISSN: 1530-0374
Publisher: United States
Grant note: HHSN268201100002I / NHLBI NIH HHS HHSN271201100004C / NIA NIH HHS HHSN268201100046C / PHS HHS HHSN268201100001C / WHI NIH HHS HHSN268201100004I / NHLBI NIH HHS HHSN271201100004C / PHS HHS HHSN268201100003C / PHS HHS HHSN268201100004C / WHI NIH HHS HHSN268201100046C / NHLBI NIH HHS R01 HL083326 / NHLBI NIH HHS HHSN268201100002C / WHI NIH HHS HHSN268201100001I / NHLBI NIH HHS HHSN268201100004C / PHS HHS HHSN268201100002C / PHS HHS HHSN268201100003C / WHI NIH HHS HHSN268201100001C / PHS HHS
Language: English
Date published: 08/2014
Academic Unit: Epidemiology; Internal Medicine
Record Identifier: 9983995105302771

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