Journal article
Calculation and Use of the Hardy‐Weinberg Model in Association Studies
Current Protocols in Human Genetics, Vol.57(1), pp.1.18.1-1.18.11
03/2008
DOI: 10.1002/0471142905.hg0118s57
PMID: 18428419
Abstract
Hardy‐Weinberg equilibrium (HWE) is an important tool for understanding population structure. If certain assumptions are met, genotype and allele frequencies can be estimated from one generation to the next. In genetic association studies, HWE principles have been applied to detect genotyping error and disease susceptibility loci. The focus of this unit is to review the key principles and assumptions of HWE. There is a brief discussion on how the significance of HWE is tested, and a review of current applications of HWE in association studies. The applications discussed include estimating penetrance, evaluating genotyping errors, testing for population stratification, and testing for association. Curr. Protoc. Hum. Genet. 57:1.18.1‐1.18.11. © 2008 by John Wiley & Sons, Inc.
Details
- Title: Subtitle
- Calculation and Use of the Hardy‐Weinberg Model in Association Studies
- Creators
- Kelli Ryckman - Vanderbilt UniversityScott M Williams - Vanderbilt University
- Resource Type
- Journal article
- Publication Details
- Current Protocols in Human Genetics, Vol.57(1), pp.1.18.1-1.18.11
- DOI
- 10.1002/0471142905.hg0118s57
- PMID
- 18428419
- ISSN
- 1934-8266
- eISSN
- 1934-8258
- Number of pages
- 11
- Language
- English
- Date published
- 03/2008
- Academic Unit
- Stead Family Department of Pediatrics; Epidemiology
- Record Identifier
- 9984214952502771
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