Journal article
Caloric restriction and body weight independently affect longevity in Wistar rats
International journal of obesity, Vol.28(3), pp.357-362
2004
DOI: 10.1038/sj.ijo.0802518
PMID: 14724654
Abstract
OBJECTIVE: To evaluate the independent effects of caloric restriction (CR) and body weight (BW) on mortality rate (MR) and the extent to which BW may mediate the effect of CR on MR.
DESIGN AND SUBJECTS: Data were from the Biosure Study, a randomized, controlled, prospective intervention study of diet regimens in 1200 Wistar rats. Animals were followed until they died spontaneously, were euthanized because of illness, or reached age 30 months.
STATISTICAL ANALYSIS: Cox regression was performed to evaluate the effects of CR and BW on MR. Bootstrap procedures were used to test the contribution of BW to the effect of CR on MR.
RESULTS: CR initiated after age 13 weeks decreased the rate of subsequent mortality. The MR increased with higher BW in early adulthood (21 weeks) and this effect persisted even after adjustment for CR. After adjustment for BW in early adulthood, we did not find a similar relation between mortality and BW in late adulthood (105 weeks). Mediation analysis indicated that low BW associated with CR appeared to mediate some of the mortality-reducing effects of CR, but CR clearly had effects independent of BW. The reductions in BW appeared to account for approximately 11% of the effect of CR.
CONCLUSION: CR and BW have independent effects on MR in Wistar rats. BW may mediate a small part of the CR effects on MR.
Details
- Title: Subtitle
- Caloric restriction and body weight independently affect longevity in Wistar rats
- Creators
- C Wang - Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, United StatesR Weindruch - Department of Medicine, Wisconsin Regional Primate Research Center, Madison, WI, United StatesJ. R Fernandez - Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, United StatesC. S Coffey - Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, United StatesP Patel - Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, United StatesD. B Allison - Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, United States
- Resource Type
- Journal article
- Publication Details
- International journal of obesity, Vol.28(3), pp.357-362
- Publisher
- Nature Publishing
- DOI
- 10.1038/sj.ijo.0802518
- PMID
- 14724654
- ISSN
- 0307-0565
- eISSN
- 1476-5497
- Language
- English
- Date published
- 2004
- Academic Unit
- Biostatistics
- Record Identifier
- 9984214716602771
Metrics
21 Record Views