Journal article
Caloric restriction improves thermotolerance and reduces hyperthermia‐induced cellular damage in old rats
The FASEB journal, Vol.14(1), pp.78-86
01/2000
DOI: 10.1096/fasebj.14.1.78
PMID: 10627282
Abstract
ABSTRACT
Adult‐onset, long‐term caloric restriction (CR) prolongs maximum life span in laboratory rodents. However, the effect of this intervention on an organism's ability to cope with a physical challenge has not been explored. We investigated the influence of CR and aging on stress tolerance in old rats exposed to an environmental heating protocol on two consecutive days. We hypothesized that CR would increase heat tolerance by reducing cellular stress and subsequent accrual of oxidative injury. All calorically restricted rats survived both heat exposures compared with only 50% of their control‐fed counterparts. CR also decreased heat‐induced radical generation, stress protein accumulation, and cellular injury in the liver. In addition, heat stress stimulated marked induction of the antioxidant enzymes manganese‐containing superoxide dismutase and catalase, along with strong nuclear catalase expression in liver samples from rats subjected to CR. In contrast, stress‐related induction of antioxidant enzymes was blunted, and nuclear catalase expression was unchanged from euthermic conditions in the control‐fed group. These data suggest that CR reduces cellular injury and improves heat tolerance of old animals by lowering radical production and preserving cellular ability to adapt to stress through antioxidant enzyme induction and translocation of these proteins to the nucleus.—Hall, D. M., Oberley, T. D., Moseley, P. M., Buettner, G. R., Oberley, L. W., Weindruch, R., Kregel, K. C. Caloric restriction improves thermotolerance and reduces hyperthermia‐induced cellular damage in old rats. FASEB J. 14, 78–86(2000)
Details
- Title: Subtitle
- Caloric restriction improves thermotolerance and reduces hyperthermia‐induced cellular damage in old rats
- Creators
- D. M HALL - The Free Radical Research InstituteT. D OBERLEY - University of Wisconsin Medical SchoolP. M MOSELEY - University of New MexicoG. R BUETTNER - The University of IowaL. W OBERLEY - The University of IowaR WEINDRUCH - Education and Clinical CenterK. C KREGEL
- Resource Type
- Journal article
- Publication Details
- The FASEB journal, Vol.14(1), pp.78-86
- DOI
- 10.1096/fasebj.14.1.78
- PMID
- 10627282
- NLM abbreviation
- FASEB J
- ISSN
- 0892-6638
- eISSN
- 1530-6860
- Publisher
- Federation of American Societies for Experimental Biology
- Number of pages
- 9
- Grant note
- National Institutes of Health (AG12350; AG14687; AG10536; DE10758; CA66081)
- Language
- English
- Date published
- 01/2000
- Academic Unit
- Radiation Oncology; Provost Office Administration; Health, Sport, and Human Physiology
- Record Identifier
- 9984046816802771
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