Calretinin expression in the differential diagnosis of human ameloblastoma and keratocystic odontogenic tumor

Patricia DeVilliers; Hao Liu; Cynthia Suggs; Darrin Simmons; Bill Daly; Shaoping Zhang; Erich Raubenheimer; Ake Larsson; Tim Wright

doi:10.1097/PAS.0b013e3181452176

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Calretinin expression in the differential diagnosis of human ameloblastoma and keratocystic odontogenic tumor

Journal article

Peer reviewed

Calretinin expression in the differential diagnosis of human ameloblastoma and keratocystic odontogenic tumor

Patricia DeVilliers, Hao Liu, Cynthia Suggs, Darrin Simmons, Bill Daly, Shaoping Zhang, Erich Raubenheimer, Ake Larsson and Tim Wright

The American journal of surgical pathology, Vol.32(2), pp.256-260

02/2008

DOI: 10.1097/PAS.0b013e3181452176

PMID: 18223328

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Abstract

Ameloblastoma is a benign, locally aggressive epithelial odontogenic tumor that has the potential to become malignant and produce metastasis to distant sites such as lungs and kidneys. The histologic presentation can be, in some instances, mistaken for keratocystic odontogenic tumor (KCOT) (formerly known as odontogenic keratocyst). The expression of calretinin [calbindin2 (CALB2)] was investigated on both ameloblastoma and KCOT. Nineteen cases of ameloblastoma and 17 cases of KCOT were stained with calretinin antiserum 18-0211 (Zymed, San Francisco, CA). All cases (100%) of ameloblastoma showed positive calretinin staining, restricted to the neoplastic epithelial component and none (0%) of the 17 KCOTs showed positive calretinin staining. Gene expression profiling of ameloblastomas showed CALB2 expressed in the basal cell layer of columnar cells resembling preameloblasts, in all 5 of the ameloblastomas evaluated. Taken together, the results of this study strongly support calretinin as a useful immunohistochemical marker for ameloblastoma and malignant ameloblastoma and it can also be used in the differential diagnosis of KCOT.

Gene Expression

Ameloblastoma - diagnosis

Diagnosis, Differential

Humans

Gene Expression Profiling

Jaw Neoplasms - metabolism

Odontogenic Cysts - genetics

Odontogenic Cysts - diagnosis

RNA, Messenger - metabolism

Ameloblastoma - genetics

S100 Calcium Binding Protein G - metabolism

Odontogenic Tumors - diagnosis

RNA, Neoplasm - analysis

Calbindin 2

Ameloblastoma - metabolism

Odontogenic Tumors - genetics

S100 Calcium Binding Protein G - genetics

Biomarkers, Tumor - metabolism

Jaw Neoplasms - diagnosis

Biomarkers, Tumor - genetics

Odontogenic Tumors - metabolism

Jaw Neoplasms - genetics

Odontogenic Cysts - metabolism

Details

Title: Subtitle: Calretinin expression in the differential diagnosis of human ameloblastoma and keratocystic odontogenic tumor
Creators: Patricia DeVilliers - Department of Pathology, University of Alabama, Birmingham, AL, USA. pdev@uab.edu
Hao Liu
Cynthia Suggs
Darrin Simmons
Bill Daly
Shaoping Zhang
Erich Raubenheimer
Ake Larsson
Tim Wright
Resource Type: Journal article
Publication Details: The American journal of surgical pathology, Vol.32(2), pp.256-260
Publisher: United States
DOI: 10.1097/PAS.0b013e3181452176
PMID: 18223328
ISSN: 0147-5185
eISSN: 1532-0979
Grant note: DE016079 / NIDCR NIH HHS
Language: English
Date published: 02/2008
Academic Unit: Periodontics
Record Identifier: 9984065720702771

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