Journal article
Can Atherosclerotic Coronary Arteries Vasodilate? An Intraoperative High-Frequency Epicardial Echocardiographic Study
The American journal of cardiology, Vol.76(1-2), pp.21-25
07/1995
DOI: 10.1016/S0002-9149(99)80794-2
PMID: 7793397
Abstract
Our purpose was to evaluate the vasodilating responses of atherosclerotic coronary arteries using intraoperativehigh-frequency (12MHz) epicardial echocardiography. We obtained continuous high-frequency epicardial echocardiographic recordings during surgery, and determined cross-sectional lumen area from 17 coronary arterial segments (12 patients). Nitrogfycerin (100 to 400μg/mfn) was administered intravenously to reduce mean (±SEM) arterial pressure 14±1.8mm Hg. The cross-sectional arterial images were classified using 3 different parameters: arterial lumen area, percentage of the arterial wall circumference that was atherosclerotic (wall thickness >0.7mm), and presence of an eccentrically shaped arterial lumen (maximal/minimal luminal diameter >1.5). Nine arterial segments had small (<5.0mm2) arterial lumens (1.7±0.40mm2 [±SEM; range 0.6 to 3.9]). With nitroglycerin, the luminal area increased 0.8±0.28mm2 (range 0 to 2.5), and 39±12.1% (range 0 to 117). The remaining 8 segments had larger (≥5.0mm2) lumens (8.7±0.91mm2 [range 5.0 to 11.9]). With nitroglycerin the luminal area increased 4.3±1.11mm2 (range 1.4 to 11.4), and 51±10.2% (range 16 to 96). Seven arterial segments had eccentric lumens; mean maximal/minimal ratio was 1.8±0.08 (range 1.6 to 2.0). The area increased 39±7.3% (range 16 to 71) with nitroglycerin. In the 10 concentrically shaped lumens (maximal/minimal lumen diameters 1.3±0.04 [range 1.1 to 1.5]), nitroglycerin increased luminal area by 48±12.6% (range 0 to 117) (p=NS). With regard to the percent arterial wall circumference that was atherosclerotic, 11 segments had 75% to 100% involvement of the arterial circumference (mean 96±2.3%). Nitroglycerin increased luminal area by 48±11.4% (range 2.3 to 117). Similar variability was seen in segments having primarily normal wall thickness (0% to 25% of circumference was abnormally thickened >0.7mm), where luminal area increased 38±18.5% (range 14 to 71). Thus, severely atherosclerotic coronary arteries retain vasodilating ability. However, the absolute and/or percent increase in luminal areas was often small, especially in the most severely diseased arteries.
Details
- Title: Subtitle
- Can Atherosclerotic Coronary Arteries Vasodilate? An Intraoperative High-Frequency Epicardial Echocardiographic Study
- Creators
- David D McPhersonSarah SirnaSteven M CollinsAllan F RossJohn R MoyersBonnie J KaneLoren F HiratzkaMelvin L MarcusRichard E Kerber
- Resource Type
- Journal article
- Publication Details
- The American journal of cardiology, Vol.76(1-2), pp.21-25
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S0002-9149(99)80794-2
- PMID
- 7793397
- ISSN
- 0002-9149
- eISSN
- 1879-1913
- Language
- English
- Date published
- 07/1995
- Academic Unit
- Anesthesia
- Record Identifier
- 9984006438502771
Metrics
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