Journal article
Can Baseline Characteristics be Used to Predict Liver Disease Outcomes in Pediatric Nonalcoholic Fatty Liver Disease?
Obesity (Silver Spring, Md.), Vol.29(1), pp.171-176
01/2021
DOI: 10.1002/oby.22999
PMID: 33185977
Abstract
Objective Longitudinal studies on childhood predictors of nonalcoholic fatty liver disease (NAFLD) progression are lacking. The objective of this study was to determine whether baseline clinical or laboratory measures predict liver disease outcomes in a pediatric NAFLD cohort. Methods A retrospective study of patients with presumed NAFLD was conducted using baseline and follow‐up clinical and laboratory measures. Disease outcomes were defined using the mean serum alanine aminotransferase (ALT) levels from 24 to 36 months after the first visit. Logistic regression assessed the relationship between ALT progression/regression and predictor variables. Multivariable regression determined the best model for predicting the ALT outcome. Markov process modeling explored the likelihood for a patient to transition between ALT states. Results Of a total of 816 patients identified, 144 had sufficient data. Regression was seen in 26%, whereas 30% progressed. No baseline clinical or laboratory measurements had a significant effect on disease outcomes. Markov modeling demonstrated that subjects were more likely to either remain in their baseline ALT group or worsen rather than improve. Conclusions Routinely obtained baseline clinical or laboratory measures cannot help risk‐stratify youth with presumed NAFLD in terms of long‐term outcomes. Close clinical, radiographic, and histologic evaluation of patients is warranted to determine those at risk of progression.
Details
- Title: Subtitle
- Can Baseline Characteristics be Used to Predict Liver Disease Outcomes in Pediatric Nonalcoholic Fatty Liver Disease?
- Creators
- Sarah Orkin - Cincinnati Children's Hospital Medical CenterToshifumi Yodoshi - Cincinnati Children's Hospital Medical CenterQin Sun - Cincinnati Children's Hospital Medical CenterLin Fei - Cincinnati Children's Hospital Medical CenterSyeda Meryum - Cincinnati Children's Hospital Medical CenterAna Catalina Arce-Clachar - Cincinnati Children's Hospital Medical CenterKristin Bramlage - Cincinnati Children's Hospital Medical CenterAndrew F. Beck - Cincinnati Children's Hospital Medical CenterMarialena Mouzaki - Cincinnati Children's Hospital Medical Center
- Resource Type
- Journal article
- Publication Details
- Obesity (Silver Spring, Md.), Vol.29(1), pp.171-176
- DOI
- 10.1002/oby.22999
- PMID
- 33185977
- NLM abbreviation
- Obesity (Silver Spring)
- ISSN
- 1930-7381
- eISSN
- 1930-739X
- Number of pages
- 6
- Language
- English
- Date published
- 01/2021
- Academic Unit
- Stead Family Department of Pediatrics; Gastroenterology, Hepatology, Pancreatology, and Nutrition
- Record Identifier
- 9985214108202771
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