Can We Cure Atherosclerosis?

Jennifer G Robinson; Michael H Davidson

doi:10.3909/ricm19S1S0003

Back

Journal article

Open access

Peer reviewed

Can We Cure Atherosclerosis?

Jennifer G Robinson and Michael H Davidson

Reviews in cardiovascular medicine, Vol.19(S1), pp.S20-S24

2018

DOI: 10.3909/ricm19S1S0003

PMID: 30207554

Files and links (1)

url

https://doi.org/10.3909/ricm19S1S0003View

Published (Version of record) Open Access

Abstract

Cardiovascular disease mortality rates have begun to rise in the United States. Based on the large body of supportive evidence, we propose a proof-of-concept, first-in-human trial to cure atherosclerosis: CURing Early ATHEROsclerosis (CURE ATHERO). This trial is based on a model of intensive induction therapy for extensive, if not complete, plaque regression, followed by intermittent maintenance therapy. An extensive body of evidence has demonstrated the causal role of apolipoprotein B lipoproteins in atherosclerosis progression and data suggest intensive low-density lipoprotein cholesterol (LDL-C) lowering may have a substantial impact on earlier stages of atherosclerosis. Compared with lifetime treatment to prevent atherosclerosis progression, this induction-intermittent treatment model will minimize costs and maximize adherence and safety.

Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage

Humans

Apolipoprotein B-100 - blood

Atherosclerosis - epidemiology

Dyslipidemias - blood

Time Factors

Atherosclerosis - diagnosis

Cholesterol, LDL - blood

Drug Therapy, Combination

Dyslipidemias - diagnosis

Serine Proteinase Inhibitors - administration & dosage

Dyslipidemias - drug therapy

Atherosclerosis - drug therapy

Drug Administration Schedule

Treatment Outcome

Biomarkers - blood

Proprotein Convertase 9 - metabolism

Plaque, Atherosclerotic

Anticholesteremic Agents - adverse effects

Randomized Controlled Trials as Topic

Atherosclerosis - blood

Dyslipidemias - epidemiology

Proprotein Convertase 9 - antagonists & inhibitors

Anticholesteremic Agents - administration & dosage

Research Design

Details

Title: Subtitle: Can We Cure Atherosclerosis?
Creators: Jennifer G Robinson - Departments of Epidemiology & Medicine, University of Iowa College of Public Health and Carver College of Medicine, Iowa City, IA
Michael H Davidson - Department of Cardiology, University of Chicago Medicine, Chicago, IL
Resource Type: Journal article
Publication Details: Reviews in cardiovascular medicine, Vol.19(S1), pp.S20-S24
DOI: 10.3909/ricm19S1S0003
PMID: 30207554
NLM abbreviation: Rev Cardiovasc Med
ISSN: 1530-6550
eISSN: 2153-8174
Publisher: United States
Language: English
Date published: 2018
Academic Unit: Epidemiology; Internal Medicine
Record Identifier: 9983995137202771

Metrics

31 Record Views

19 Times Cited - Web of Science